GSDME-mediated Pyroptosis Antibody Panel (CASP3, GSDME, HMGB1)
CAT#: VS-0725-YC30
The GSDME-mediated Pyroptosis Antibody Panel are sets of 3 antibodies, precisely chosen for the simultaneous detection of key proteins involved in this particular cell death pathway. Our comprehensive set includes antibodies against CASP3, GSDME, and HMGB1. This panel offers a streamlined approach for researchers studying programmed cell death, inflammation, and therapeutic strategies, ensuring accurate and reproducible results for your cutting-edge experiments.
| Sub Cat | Component Name | Clone | Type | Target | Species Reactivity | Applications | |
| HPAB-0215-FY | Mouse Anti-HMGB1 Recombinant Antibody (clone 3E8) | 3E8 | Mouse IgG | HMGB1 | Human | Block, WB | |
| VS3-FY621 | Recombinant Rabbit Anti-GSDME Antibody (clone R09-7C1) | R09-7C1 | Rabbit IgG | GSDME | Human | Western Blot, Immunoprecipitation | |
| VS3-FY192 | Recombinant Rabbit Anti-CASP3 Antibody (clone R02-7C2) | R02-7C2 | Rabbit IgG | CASP3 | Human | Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunocytochemistry, Immunofluorescence, Immunoprecipitation |
More Infomation
Specifications
- Targets
- CASP3, GSDME, HMGB1
- Species Reactivity
- Human
- Research Area
- GSDME-mediated Pyroptosis
- Introduction
- GSDME-mediated pyroptosis is a distinct and increasingly recognized pathway of regulated cell death (RCD) that highlights a crucial intersection between the traditionally "silent" apoptotic process and the highly "inflammatory" pyroptotic cell death. While canonical and non-canonical pyroptosis primarily depend on inflammatory caspases (Caspase-1, -4, -5, -11) cleaving Gasdermin D (GSDMD), the discovery of Gasdermin E (GSDME, also known as DFNA5) as a substrate for apoptotic caspases has unveiled an alternative route to pyroptosis.
- Storage
- Store at 4°C for up to a week. For long-term storage, store at -20°C or below.
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