H-2Kb/Mouse mTERT (VGRNFTNL) MHC Monomer
CAT#: MHC-YF144
This product is a MHC monomer of biotinylated peptide/MHC complex composed mTERT-derived peptide of VGRNFTNL sequence covering 198-205 and H-2Kb molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line LHCN-M2
Immunofluorescent staining of human cell line LHCN-M2 shows localization to nucleoplasm & nuclear speckles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/1782_B1_17_cr596b5f3cb51d0_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows no positivity in hepatocytes and bile duct cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_9_4_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54641/142147_A_7_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164362-TERT/subcellular
❮
❯
Specifications
- Allele
- H-2Kb
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- mTERT
- Antigen Species
- Mouse
- Peptide
- VGRNFTNL
- Range
- 198-205
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
- Alternative Names
- TR; TP2; TRT; EST2; TCS1
- Gene ID
- 21752
- UniProt ID
- Q9JLM1
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Datasheet
MSDS
COA
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