H-2Kd/Human IGRP (VYLKTNVFL) MHC Monomer
CAT#: MHC-YF145
This product is a MHC monomer of biotinylated peptide/MHC complex composed IGRP-derived peptide of VYLKTNVFL sequence covering 206-214 and H-2Kd molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2Kd
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- IGRP
- Antigen Species
- Human
- Peptide
- VYLKTNVFL
- Range
- 206-214
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined.
- Alternative Names
- G6PC2; glucose-6-phosphatase catalytic subunit 2; IGRP
- Gene ID
- 57818
- UniProt ID
- Q9NQR9
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High Quality IGRP Monomer
This biotinylated H-2Kd monomer loaded with the IGRP peptide VYLKTNVFL was perfect for creating our own tetramers. The protein quality is excellent, allowing for efficient multimerization and subsequent detection of diabetes-relevant T cells in our assays.
Essential For Diabetes Research
We rely on this monomer to study autoimmunity against Glucose-6-phosphatase catalytic subunit 2. The peptide-MHC complex is stable and allows us to generate specific reagents for tracking antigen-specific CD8 T cells in our experimental models.
Q&As
-
What does IGRP stand for and where is it found?
A: IGRP stands for Islet-specific glucose-6-phosphatase catalytic subunit-related protein (encoded by G6PC2). It is found in pancreatic islets and is a major target of cell-mediated autoimmunity in diabetes.
-
Can this monomer be used directly for flow cytometry?
A: No, this product is an MHC Monomer labeled with biotin. To use it for flow cytometry detection of T cells, it must first be multimerized, typically by mixing with fluorescently labeled streptavidin to form tetramers.
View the frequently asked questions answered by Creative Biolabs Support.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "G6PC2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC668 | PE-A*02:01/Human IGRP (VLFGLGFAI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC669 | APC-A*02:01/Human IGRP (VLFGLGFAI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC670 | BV421-A*02:01/Human IGRP (VLFGLGFAI) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0693 | PE-A*02:01/Human G6PC2 (LNIDLLWSV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0694 | APC-A*02:01/Human G6PC2 (LNIDLLWSV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0695 | FITC-A*02:01/Human G6PC2 (LNIDLLWSV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0696 | A*02:01/Human G6PC2 (LNIDLLWSV) MHC Tetramer | FCM, IHC |
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