Anti-Cripto protein (huB3F6)-Disulfide-linker-DM4 ADC (CAT#: ADC-094LCT)

• Antibody Overview
• huB3F6 (Humanized IgGl / kappa monoclonal Antibody)

• Clone
• huB3F6

• Linker
• Disulfide-linker

• Linker Class/Description
• Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)

• Drug Class/Description
• Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

• Introduction
• This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

• Alternative Names
• TDGF1; teratocarcinoma-derived growth factor 1; CR; CRGF; CRIPTO; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1;

• Gene ID
• 6997

• UniProt ID
• F5H1T8

• ADC-031LZY
• Anti-cripto (clone huB3F6)-SPDB-DM4 ADC

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