Anti-TMEFF2 (huPr1)-vcMMAE ADC
CAT#: ADC-169LCT
This ADC product is composed of an anti-TMEFF2 antibody (clone huPr1) conjuagated via a vc linker to MMAE (huPr1-vcMMAE). It has demonstrated a response in metastatic and hormone-resistant prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_5_6.jpg
Normal Tissue
Figure 6 Prostate
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_2_5.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (AF22, LHCN-M2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000144339-TMEFF2
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Specifications
- Antibody Overview
- Humanized Anti-TMEFF2
- Clone
- huPr1
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants.
- Alternative Names
- TMEFF2; transmembrane protein with EGF-like and two follistatin-like domains 2; TR; HPP1; TPEF; TENB2; CT120.2; tomoregulin-2; TR-2; tomoregulin; transmembrane protein TENB2; hyperplastic polyposis protein 1; cancer/testis antigen family 120, member 2;
- Gene ID
- 23671
- UniProt ID
- Q9UIK5
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See other products for "TMEFF2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3543z | Mouse Anti-TMEFF2 Recombinant Antibody (MOB-3543z) | ELISA, IHC, WB, IF | Mouse IgG |
| HPAB-0022-LS | Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19) | ELISA | Humanized IgG |
| VS4-CJ136 | Recombinant Human Anti-TMEFF2 Antibody (clone 6G6) | ELISA | Human IgG4 (S228P) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3543z-F(E) | Recombinant Anti-Human TMEFF2 Antibody Fab Fragment | IF, FuncS | Fab |
| HPAB-0022-LS-F(E) | Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3543z-S(P) | Recombinant Anti-Human TMEFF2 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| HPAB-0022-LS-S(P) | Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0284CL | Anti-Human TMEFF2 Recombinant Antibody (PQ01 (#001)) | ELISA, WB, FuncS | |
| TAB-0284CL-S(P) | Anti-Human TMEFF2 Recombinant Antibody scFv Fragment (PQ01 (#001)) | ELISA, WB, FuncS | |
| TAB-0284CL-F(E) | Anti-Human TMEFF2 Recombinant Antibody Fab Fragment (PQ01 (#001)) | ELISA, WB, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-594CT | Humanized Anti-TMEFF2 Recombinant Antibody (TAB-594CT) | ELISA, FC, IHC | Humanized antibody |
| TAB-594CT-S(P) | Humanized Anti-TMEFF2 Recombinant Antibody; scFv Fragment (TAB-594CT-S(P)) | ELISA, FC, IHC | Humanized scFv |
| TAB-594CT-F(E) | Humanized Anti-TMEFF2 Recombinant Antibody; Fab Fragment (TAB-594CT-F(E)) | ELISA, FC, IHC | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-158CQ | Anti-Human TMEFF2 Recombinant Antibody (AT-19) | ELISA, FC, IF | Human antibody |
| TAB-158CQ-S(P) | Anti-Human TMEFF2 Recombinant Antibody scFv Fragment (AT-19) | ELISA, FC, IF | Human antibody |
| TAB-158CQ-F(E) | Anti-Human TMEFF2 Recombinant Antibody Fab Fragment (AT-19) | ELISA, FC, IF | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3590 | Rabbit Anti-TMEFF2 Recombinant Antibody (clone DS3590AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1163 | CytoStream™ Rabbit Anti-TMEFF2 Recombinant Antibody (VS13-YC1163) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2300 | Anti-TMEFF2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7326 | Anti-Mouse TMEFF2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7325 | Anti-Human TMEFF2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC113 | Recombinant Anti-TMEFF2 Vesicular Antibody, EV Displayed (VS-0425-YC113) | ELISA, FC, Cell-uptake |
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