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Anti-TMEFF2 (huPr1)-vcMMAE ADC (CAT#: ADC-169LCT)

This ADC product is composed of an anti-TMEFF2 antibody (clone huPr1) conjuagated via a vc linker to MMAE (huPr1-vcMMAE). It has demonstrated a response in metastatic and hormone-resistant prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 Cerebral cortex
Figure 1 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_B_7_5.jpg
Figure 2 Colon
Figure 2 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_9_3.jpg
Figure 3 Liver
Figure 3 Liver
(Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_9_4.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_5_6.jpg
Figure 6 Prostate
Figure 6 Prostate
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_2_5.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15587/35964_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (AF22, LHCN-M2)
Figure 8 RNA cell line category: Group enriched (AF22, LHCN-M2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000144339-TMEFF2

Specifications

  • Antibody Overview
  • Humanized Anti-TMEFF2
  • Clone
  • huPr1
  • Linker
  • VC (valine-citrulline)
  • Linker Class/Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • TMEFF2; transmembrane protein with EGF-like and two follistatin-like domains 2; TR; HPP1; TPEF; TENB2; CT120.2; tomoregulin-2; TR-2; tomoregulin; transmembrane protein TENB2; hyperplastic polyposis protein 1; cancer/testis antigen family 120, member 2;

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See other products for "TMEFF2"

Recombinant Antibody

CAT Product Name Application Type
MOB-3543z Mouse Anti-TMEFF2 Recombinant Antibody (MOB-3543z) ELISA, IHC, WB, IF Mouse IgG
HPAB-0022-LS Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19) ELISA Humanized lgG
VS4-CJ136 Recombinant Human Anti-TMEFF2 Antibody (clone 6G6) ELISA Human IgG4 (S228P)

Fab Fragment Antibody

CAT Product Name Application Type
MOB-3543z-F(E) Recombinant Anti-Human TMEFF2 Antibody Fab Fragment IF, FuncS Fab
HPAB-0022-LS-F(E) Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19); Fab Fragment ELISA Humanized Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-3543z-S(P) Recombinant Anti-Human TMEFF2 Antibody scFv Fragment ELISA, WB, FuncS scFv
HPAB-0022-LS-S(P) Mouse Anti-TMEFF2 Recombinant Antibody (clone TMEFF2#19); scFv Fragment ELISA Humanized scFv

Mouse Antibody

CAT Product Name Application Type
TAB-0284CL Anti-Human TMEFF2 Recombinant Antibody (PQ01 (#001)) ELISA, WB, FuncS
TAB-0284CL-S(P) Anti-Human TMEFF2 Recombinant Antibody scFv Fragment (PQ01 (#001)) ELISA, WB, FuncS
TAB-0284CL-F(E) Anti-Human TMEFF2 Recombinant Antibody Fab Fragment (PQ01 (#001)) ELISA, WB, FuncS

Humanized Antibody

CAT Product Name Application Type
TAB-594CT Humanized Anti-TMEFF2 Recombinant Antibody (TAB-594CT) ELISA, FC, IHC Humanized antibody
TAB-594CT-S(P) Humanized Anti-TMEFF2 Recombinant Antibody; scFv Fragment (TAB-594CT-S(P)) ELISA, FC, IHC Humanized scFv
TAB-594CT-F(E) Humanized Anti-TMEFF2 Recombinant Antibody; Fab Fragment (TAB-594CT-F(E)) ELISA, FC, IHC Humanized Fab

Human Antibody

CAT Product Name Application Type
TAB-158CQ Anti-Human TMEFF2 Recombinant Antibody (AT-19) ELISA, FC, IF Human antibody
TAB-158CQ-S(P) Anti-Human TMEFF2 Recombinant Antibody scFv Fragment (AT-19) ELISA, FC, IF Human antibody
TAB-158CQ-F(E) Anti-Human TMEFF2 Recombinant Antibody Fab Fragment (AT-19) ELISA, FC, IF Human antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3590 Rabbit Anti-TMEFF2 Recombinant Antibody (clone DS3590AB) WB Rabbit IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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