Human Anti-AMHR2 (clone 7) scFv-Fc Chimera (CAT#: VS-0325-FY14)
The anti-AMHR2 scFv-Fc antibody is a recombinant protein designed to specifically bind to the AMHR2 receptor, which plays a significant role in various physiological processes, including reproductive biology and certain pathologies. The scFv-Fc from clone 7 exhibits specific affinity for IGROV-1 cells that express the MISIIR.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm, cytosol & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/60228/1825_H2_27_cr5abb93a3dd6f8_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm, cytosol & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/60228/1825_H2_27_cr5abb93a3dd6f8_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69636/1512_E10_5_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69636/1512_E10_5_selected.jpg
Figure 3 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/60228/1519_G11_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/60228/1519_G11_1_blue_red_green.jpg
Figure 4 IF staining of human cell line A-434
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/60228/1504_D8_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/60228/1504_D8_1_blue_red_green.jpg
Figure 5 RNA cell line category: Group enriched (HEL, K-562)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135409-AMHR2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135409-AMHR2
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human AMHR2
- Species Reactivity
- Human
- Clone
- clone 7
- Applications
- Flow Cytometry, Surface Plasmon Resonance
- Related Disease
- Human cervical cancer, prostate cancer, mammary epithelium, breast cancer, breast fibroadnoma, breast tumor, ductal carcinoma
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Anti-Mullerian Hormone Receptor Type 2; Muellerian Inhibiting Substance Type II Receptor; Anti-Muellerian Hormone Type II Receptor; AMH Type II Receptor; MIS Type II Receptor; EC 2.7.11.30; MISRII; MISR2
- Gene ID
- 269
- UniProt ID
- Q16671
- Long Name
- Anti-Mullerian Hormone Receptor Type 2
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn66 and Asn119
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- XP_011536475.1; XP_011536476.1; XP_011536478.1; XP_011536480.1; XP_011536481.1
- Function
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
Receptor for anti-Muellerian hormone.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-56 | Recombinant Anti-AMHR2 Antibody | WB, ELISA, IHC, FuncS | IgG |
| MHH-56 | Recombinant Human Anti-AMHR2 Antibody | ELISA, FuncS | IgG |
| MHH-57 | Recombinant Human Anti-AMHR-II Antibody | IP, IF, Biosensors, FuncS | IgG |
| MOB-0609MZ | Mouse Anti-AMHR2 Recombinant Antibody (clone NJH8) | ELISA, IHC-P, WB | Mouse IgG1 |
| VS-0723-WK218 | Rabbit Anti-AMHR2 Recombinant Antibody (VS-0723-WK218) | ELISA, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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