Human Anti-BMPR2 scFv-Fc Chimera (VS-0325-FY92) (CAT#: VS-0325-FY92)
The anti-BMPR-2 scFv-Fc antibody targets the Bone Morphogenetic Protein Receptor 2 (BMPR-2), a receptor involved in cell differentiation and vascular homeostasis. It has potential therapeutic applications in treating diseases associated with BMPR-2 dysfunction, such as pulmonary arterial hypertension. The scFv-Fc design provides extended half-life and enhanced binding affinity, improving its therapeutic potential.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49014/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49014/if_selected.jpg
Figure 2 IHC staining of human spleen
(Immunohistochemical staining of human spleen shows distinct cytoplasmic positivity in cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/ihc_selected.jpg
(Immunohistochemical staining of human spleen shows distinct cytoplasmic positivity in cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_B_7_5.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_B_7_5.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_8_3.jpg
Figure 5 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_8_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_8_4.jpg
Figure 6 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_7_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_7_5.jpg
Figure 7 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_5_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_5_6.jpg
Figure 8 Heart muscle
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_B_4_6.jpg
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_B_4_6.jpg
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204217-BMPR2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204217-BMPR2
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human BMPR2
- Species Reactivity
- Human
- Applications
- Immunoassay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Bone Morphogenetic Protein Receptor Type 2; Bone Morphogenetic Protein Receptor Type II; Bone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase); BMP Type II Receptor; BMP Type-2 Receptor; EC 2.7.11.30; BMPR-II; PPH1; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type-2
- Gene ID
- 659
- UniProt ID
- Q13873
- Long Name
- Bone Morphogenetic Protein Receptor Type 2
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn55, Asn110, Asn126, and Asn827
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect BMPR2_HUMAN (1046)
Glycosylation from GlyGen 6 sites, 5 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_011509989.1; XP_054199481.1; NP_001195.2
- Function
- BMPR2 (Bone morphogenetic protein receptor type 2) is a receptor involved in BMP signaling, which is crucial for pulmonary arterial hypertension. It plays a role in cell proliferation, differentiation, and apoptosis, and its dysfunction leads to vascular remodeling.
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
TGF-β Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "BMPR2"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1502MZ | Mouse Anti-BMPR2 Recombinant Antibody (clone NN0070-0B20) | FC, IHC-P, WB | Mouse IgG1 |
| ZG-0340F | Mouse Anti-BMPR2 Recombinant Antibody (ZG-0340F) | WB, IHC, ELISA | Mouse IgG |
| ZG-0341F | Mouse Anti-BMPR2 Recombinant Antibody (ZG-0341F) | WB, IHC, IF, ELISA | Mouse IgG |
| VS3-QX125 | Mouse Anti-BMPR2 Recombinant Antibody (clone 3F6) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-WK97 | Mouse Anti-BMPR2 Recombinant Antibody (clone F8-G6) | WB, ELISA | Mouse IgG1 |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0325-FY92. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: FC, FRET, Internalization
Application: ELISA, Block, WB, FC, IP
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
