Human Anti-BMPR2 scFv-Fc Chimera (VS-0325-FY92)
CAT#: VS-0325-FY92
The anti-BMPR-2 scFv-Fc antibody targets the Bone Morphogenetic Protein Receptor 2 (BMPR-2), a receptor involved in cell differentiation and vascular homeostasis. It has potential therapeutic applications in treating diseases associated with BMPR-2 dysfunction, such as pulmonary arterial hypertension. The scFv-Fc design provides extended half-life and enhanced binding affinity, improving its therapeutic potential.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49014/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human spleen
Immunohistochemical staining of human spleen shows distinct cytoplasmic positivity in cells in red pulp.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_A_5_6.jpg
Normal Tissue
Figure 8 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17385/40602_B_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204217-BMPR2
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human BMPR2
- Species Reactivity
- Human
- Applications
- Immunoassay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Bone Morphogenetic Protein Receptor Type 2; Bone Morphogenetic Protein Receptor Type II; Bone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase); BMP Type II Receptor; BMP Type-2 Receptor; EC 2.7.11.30; BMPR-II; PPH1; Type II Receptor For Bone Morphogenetic Protein-4; Bone Morphogenetic Protein Receptor Type-2
- Gene ID
- 659
- UniProt ID
- Q13873
- Long Name
- Bone Morphogenetic Protein Receptor Type 2
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn55, Asn110, Asn126, and Asn827
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect BMPR2_HUMAN (1046)
Glycosylation from GlyGen 6 sites, 5 N-linked glycans (2 sites), 2 O-linked glycans (2 sites)
- Protein Refseq
- XP_011509989.1; XP_054199481.1; NP_001195.2
- Function
- BMPR2 (Bone morphogenetic protein receptor type 2) is a receptor involved in BMP signaling, which is crucial for pulmonary arterial hypertension. It plays a role in cell proliferation, differentiation, and apoptosis, and its dysfunction leads to vascular remodeling.
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Related Signaling Pathways
TGF-β Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "BMPR2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1502MZ | Mouse Anti-BMPR2 Recombinant Antibody (clone NN0070-0B20) | FC, IHC-P, WB | Mouse IgG1 |
| ZG-0340F | Mouse Anti-BMPR2 Recombinant Antibody (ZG-0340F) | WB, IHC, ELISA | Mouse IgG |
| ZG-0341F | Mouse Anti-BMPR2 Recombinant Antibody (ZG-0341F) | WB, IHC, IF, ELISA | Mouse IgG |
| VS3-QX125 | Mouse Anti-BMPR2 Recombinant Antibody (clone 3F6) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-WK97 | Mouse Anti-BMPR2 Recombinant Antibody (clone F8-G6) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY54 | Mouse Anti-NHP BMPR2 Recombinant Antibody (clone 3F6F8) | WB, IF, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY806 | Anti-BMPR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY807 | Anti-Mouse BMPR2 Immunohistochemistry Kit | IHC |
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