Human Anti-GAS6 scFv-Fc Chimera (VS-0425-FY24)
CAT#: VS-0425-FY24
The anti-GAS6 scFv-Fc Antibody represents a promising therapeutic agent for targeting the GAS6/AXL pathway in various diseases. Its unique structure and mechanism of action provide several advantages over traditional monoclonal antibodies, making it a valuable tool for further research and development in the field of targeted therapy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/56080/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human testis
Immunohistochemical staining of human testis shows cytoplasmic positivity in cells in seminiferous ducts and Leydig cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8275/23223_A_4_6_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8275/23223_B_8_5.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8275/23223_A_7_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, HSkMC, RPMI-8226)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183087-GAS6
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Specifications
- Immunogen
- Human Gas6 protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GAS6
- Species Reactivity
- Human
- Applications
- Inhibition, ELISA
- Related Disease
- Kidney or cancer disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Growth Arrest Specific 6; AXL Receptor Tyrosine Kinase Ligand; AXL Stimulatory Factor; AXLLG; Growth Arrest-Specific Protein 6; GAS-6; AXSF
- Gene ID
- 2621
- UniProt ID
- Q14393
- Long Name
- Growth Arrest Specific 6
- Cellular Localization
- Secreted
- Post Translation Modifications
- [Isoform 2]: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.
These residues are essential for the binding of calcium.
Glycosylation at Asn420
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites, 5 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054230397.1; NP_000811.1
- Function
- Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration.
GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6_HUMAN,Q14393
(Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry.
Plays a role in Dengue cell entry by apoptotic mimicry.
Plays a role in Vaccinia virus cell entry by apoptotic mimicry.
Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "GAS6"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0061-CN-S(P) | Human Anti-GAS6 Recombinant Antibody; scFv Fragment (HPAB-0061-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-N0098-YC-S(P) | Human Anti-GAS6 Recombinant Antibody; scFv Fragment (HPAB-N0098-YC-S(P)) | ELISA, Inhib | Humanized scFv |
| HPAB-J0105-YC-S(P) | Mouse Anti-GAS6 Recombinant Antibody; scFv Fragment (HPAB-J0105-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0106-YC-S(P) | Mouse Anti-GAS6 Recombinant Antibody; scFv Fragment (HPAB-J0106-YC-S(P)) | ELISA, Inhib | Mouse scFv |
| HPAB-J0107-YC-S(P) | Rat Anti-GAS6 Recombinant Antibody; scFv Fragment (HPAB-J0107-YC-S(P)) | ELISA, Inhib | Rat scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0061-CN-F(E) | Human Anti-GAS6 Recombinant Antibody; Fab Fragment (HPAB-0061-CN-F(E)) | ELISA, Neut | Human Fab |
| HPAB-N0098-YC-F(E) | Human Anti-GAS6 Recombinant Antibody; Fab Fragment (HPAB-N0098-YC-F(E)) | ELISA, Inhib | Humanized Fab |
| HPAB-J0105-YC-F(E) | Mouse Anti-GAS6 Recombinant Antibody; Fab Fragment (HPAB-J0105-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0106-YC-F(E) | Mouse Anti-GAS6 Recombinant Antibody; Fab Fragment (HPAB-J0106-YC-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-J0107-YC-F(E) | Rat Anti-GAS6 Recombinant Antibody; Fab Fragment (HPAB-J0107-YC-F(E)) | ELISA, Inhib | Chimeric (mouse/rat) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1013LC | Mouse Anti-GAS6 Recombinant Antibody (clone CNTO300) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0105-YC | Mouse Anti-GAS6 Recombinant Antibody (HPAB-J0105-YC) | ELISA, Inhib | Mouse IgG |
| HPAB-J0106-YC | Mouse Anti-GAS6 Recombinant Antibody (HPAB-J0106-YC) | ELISA, Inhib | Mouse IgG |
| HPAB-J0107-YC | Rat Anti-GAS6 Recombinant Antibody (HPAB-J0107-YC) | ELISA, Inhib | Chimeric (mouse/rat) IgG1, κ |
| HPAB-J0108-YC | Rat Anti-GAS6 Recombinant Antibody (HPAB-J0108-YC) | ELISA, Inhib | Chimeric (mouse/rat) IgG1, κ |
| HPAB-J0109-YC | Human Anti-GAS6 Recombinant Antibody (HPAB-J0109-YC) | ELISA, Inhib | Humanized IgG |
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