Human Anti-GAS6 scFv-Fc Chimera (VS-0425-FY24) (CAT#: VS-0425-FY24)

• Immunogen
• Human Gas6 protein.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human GAS6

• Species Reactivity
• Human

• Applications
• Inhibition, ELISA

• Related Disease
• Kidney or cancer disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Growth Arrest Specific 6; AXL Receptor Tyrosine Kinase Ligand; AXL Stimulatory Factor; AXLLG; Growth Arrest-Specific Protein 6; GAS-6; AXSF

• Gene ID
• 2621

• UniProt ID
• Q14393

• Long Name
• Growth Arrest Specific 6

• Cellular Localization
• Secreted

• Post Translation Modifications
• [Isoform 2]: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
  Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.
  These residues are essential for the binding of calcium.
  Glycosylation at Asn420
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 3 sites, 5 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

• Protein Refseq
• XP_054230397.1; NP_000811.1

• Function
• Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration.
  GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6_HUMAN,Q14393
  (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry.
  Plays a role in Dengue cell entry by apoptotic mimicry.
  Plays a role in Vaccinia virus cell entry by apoptotic mimicry.
  Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry

Select a product category from the dropdown menu below to view related products.