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    Recombinant Human Anti-GNL3 Soluble TCR (CH6) (ZIP-Fos/ZIP-Jun) (CAT#: VS-0622-YF1157)

    Human TCR (CH6) recognizes GNL3 peptide (NLNRCSVPV) in the context of HLA-A*02:01. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant Human soluble TCR (CH6). Please note that the activity is not guaranteed.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli rim.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/20770/615_A8_2_selected.jpg
    Figure 2 IHC staining of human oral mucosa
    Figure 2 IHC staining of human oral mucosa
    (Immunohistochemical staining of human oral mucosa shows strong nucleolar positivity in squamous epithelial cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/20770/47136_A_8_1_selected.jpg
    Figure 3 IF staining of human cell line A-431
    Figure 3 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoli rim.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/20770/621_A8_3_blue_red_green.jpg
    Figure 4 IF staining of human cell line U-251 MG
    Figure 4 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli rim.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/20770/612_A8_1_blue_red_green.jpg
    Normal Tissue
    Figure 5 Cerebral cortex
    Figure 5 Cerebral cortex
    (Neuronal cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36742/124388_B_8_5.jpg
    Figure 6 Colon
    Figure 6 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Peripheral nerve/ganglion
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36742/124388_A_9_3.jpg
    Figure 7 Liver
    Figure 7 Liver
    (Hepatocytes
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36742/124388_A_7_4.jpg
    Figure 8 Kidney
    Figure 8 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36742/124388_A_9_5.jpg
    Figure 9 Testis
    Figure 9 Testis
    (Cells in seminiferous ducts
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Leydig cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36743/124399_A_5_6.jpg
    Figure 10 Skin
    Figure 10 Skin
    (Fibroblasts
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Keratinocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Langerhans
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Melanocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36742/124388_B_9_1.jpg
    Figure 11 Lymph node
    Figure 11 Lymph node
    (Germinal center cells
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Nuclear
    Non-germinal center cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36742/124388_A_8_8.jpg
    RNA Expression
    Figure 12 RNA cell line category: Low cell line specificity
    Figure 12 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163938-GNL3

    Specifications

    • Host Species
    • Human
    • Target
    • GNL3
    • Species Reactivity
    • Human
    • Epitope
    • NLNRCSVPV
    • MHC
    • HLA-A*02:01
    • Clone
    • CH6
    • Type
    • Soluble TCR (ZIP-Fos/ZIP-Jun)
    • Related Disease
    • Pancreatic cancer
    • TCR Expression Strategy
    • ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.

    Target

    • Alternative Names
    • C77032, E2IG3, NNP47, NS

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