Human Anti-HLA-A2 scFv-Fc Chimera (VS-0325-FY11) (CAT#: VS-0325-FY11)
Anti-HLA-A2 scFv-Fc is a recombinant antibody that combines the antigen-binding capabilities of a single-chain variable fragment (scFv) with the effector functions of an immunoglobulin's fragment crystallizable (Fc) region. Anti-HLA-A2 scFv-Fc can be used to study the therapeutic potential of regulatory T cells (Tregs) in transplantation models. The scFv-Fc antibody targets the HLA-A2 molecule displaying the WT1126 peptide on leukemia cells, promoting antibody-dependent cell-mediated cytotoxicity (ADCC) through the activation of NK-92-MI cells.
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human HLA-A2
- Species Reactivity
- Human
- Applications
- ELISA, ADCC
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- MHC Class I, A cell surface antigen; HLA-A2
- Long Name
- MHC Class I, A cell surface antigen
- Function
- HLA-A*02 is one particular class I major histocompatibility complex (MHC) allele group at the HLA-A locus. The A*02 allele group can code for many proteins; as of December 2013 there are 456 different HLA-A*02 proteins. Serotyping can identify as far as HLA-A*02, which is typically enough to prevent transplant rejection (the original motivation for HLA identification). Genes can further be separated by genetic sequencing and analysis. HLAs can be identified with as many as nine numbers and a letter (ex. HLA-A*02:101:01:02N). HLA-A*02 is globally common, but particular variants of the allele can be separated by geographic prominence.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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MHC Tetramer Products for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-13 | Recombinant Anti-human A*02 Antibody | WB, IHC, FuncS | IgG |
| MHH-13 | Recombinant Human Anti-human A*02 Antibody | IF, FC, FuncS | IgG |
| FAMAB-0167YC | Mouse Anti-HLA-A2 Recombinant Antibody (clone G1) | ELISA, FC, IHC, Cyt | Mouse IgG |
| FAMAB-0157JF | Human Anti-HLA-A2 Recombinant Antibody (clone 3PC4) | WB, FC | Human IgG |
| FAMAB-0158JF | Human Anti-HLA-A2 Recombinant Antibody (clone 3PF12) | WB, FC, Inhib | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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