Human Anti-IGSF8 scFv-Fc Chimera (VS-0325-FY21) (CAT#: VS-0325-FY21)
The anti-IGSF8 scFv-Fc antibody targets IGSF8, a member of the immunoglobulin superfamily involved in cell adhesion and signaling. It has potential therapeutic applications in diseases associated with IGSF8 dysregulation, such as certain cancers and inflammatory disorders. The scFv-Fc format enhances its stability and bioavailability, making it suitable for therapeutic use.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11917/1680_E3_6_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11917/1680_E3_6_selected.jpg
Figure 2 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/1802_H1_5_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/1802_H1_5_selected.jpg
Figure 3 IHC staining of human cerebellum
(Immunohistochemical staining of human cerebellum shows strong positivity in neuronal processes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11917/29657_B_8_8_selected.jpg
(Immunohistochemical staining of human cerebellum shows strong positivity in neuronal processes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11917/29657_B_8_8_selected.jpg
Figure 4 IHC staining of human spleen
(Immunohistochemical staining of human spleen shows strong nuclear and cytoplasmic positivity in cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_B_7_4_selected.jpg
(Immunohistochemical staining of human spleen shows strong nuclear and cytoplasmic positivity in cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_B_7_4_selected.jpg
Figure 5 Cerebral cortex
(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_B_8_5.jpg
(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_B_8_5.jpg
Figure 6 Colon
(Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_A_9_3.jpg
(Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_A_9_3.jpg
Figure 7 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_A_7_5.jpg
Figure 8 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/75970/169279_A_4_6.jpg
Figure 9 RNA cell line category: Cell line enhanced (SK-MEL-30)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162729-IGSF8
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162729-IGSF8
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IGSF8
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Cancer and inflammatory disorder
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Immunoglobulin Superfamily Member 8
- Gene ID
- 93185
- UniProt ID
- Q969P0
- Long Name
- Immunoglobulin Superfamily Member 8
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn50, Asn327, and Asn463
Ubiquitination at Lys143
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect IGSF8_HUMAN (1394)
Glycosylation from GlyGen 4 sites, 35 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016858324.1; XP_016858325.1; XP_016858326.1; XP_016858328.1; XP_024306713.1
- Function
- Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity (PubMed:11504738, 14662754).
Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IGSF8"
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IgG Antibody Products
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3451z | Mouse Anti-IGSF8 Recombinant Antibody (MOB-3451z) | ELISA | Mouse IgG1, κ |
| CBPAB-050LC | Rabbit Anti-IGSF8 Polyclonal Antibody | IHC, WB, IF | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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