Human Anti-KCNA3 scFv-Fc Chimera (VS-0325-FY53)
CAT#: VS-0325-FY53
The anti-KCNA3 scFv-Fc antibody targets KCNA3, a voltage-gated potassium channel subunit involved in neuronal excitability and signal transduction. It is useful for studying the role of KCNA3 in neurophysiology, epilepsy, and other neurological disorders.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in Astrocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16625/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16625/39156_B_9_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177272-KCNA3
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The antibody specifically binds to a human Kv1.3 protein.
- Species Reactivity
- Human
- Applications
- Inhibition
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Potassium Voltage-Gated Channel Subfamily A Member 3; Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3; Voltage-Gated Potassium Channel Subunit Kv1.3; Voltage-Gated K(+) Channel HuKIII; HPCN3; HGK5; HLK3; Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 3; Voltage-Gated Potassium Channel Protein Kv1.3
- Gene ID
- 3738
- UniProt ID
- P22001
- Long Name
- Potassium Voltage-Gated Channel Subfamily A Member 3
- Sequence Similarities
- Belongs to the potassium channel family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylation promotes the cell surface expression.
Phosphorylation on Tyr-499 inhibits its channel activity.
Glycosylation at Asn279
Ubiquitination at Lys120 and Lys526
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_002223.3
- Function
- KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a potassium channel involved in regulating neuronal excitability. It plays a crucial role in action potential repolarization and is implicated in neurological disorders.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "KCNA3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0634CL | Human Anti-KCNA3 Recombinant Antibody (TAB-0634CL) | ELISA | Humanized IgG |
| TAB-0634CL-S(P) | Human Anti-KCNA3 Recombinant Antibody; scFv Fragment (TAB-0634CL-S(P)) | ELISA | Humanized scFv |
| TAB-0634CL-F(E) | Human Anti-KCNA3 Recombinant Antibody; Fab Fragment (TAB-0634CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2301CT | Recombinant Mouse anti-Human KCNA3 Monoclonal antibody (FQS5599) | WB, IHC-P, IHC-Fr, ICC, IF |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC320 | Recombinant Anti-KCNA3 Vesicular Antibody, EV Displayed (VS-0425-YC320) | ELISA, FC, Cell-uptake |
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