Human Anti-KCNA3 scFv-Fc Chimera (VS-0325-FY53) (CAT#: VS-0325-FY53)
The anti-KCNA3 scFv-Fc antibody targets KCNA3, a voltage-gated potassium channel subunit involved in neuronal excitability and signal transduction. It is useful for studying the role of KCNA3 in neurophysiology, epilepsy, and other neurological disorders.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in Astrocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16625/ihc_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in Astrocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16625/ihc_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16625/39156_B_9_5.jpg
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16625/39156_B_9_5.jpg
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177272-KCNA3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177272-KCNA3
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The antibody specifically binds to a human Kv1.3 protein.
- Species Reactivity
- Human
- Applications
- Inhibition
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Potassium Voltage-Gated Channel Subfamily A Member 3; Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3; Voltage-Gated Potassium Channel Subunit Kv1.3; Voltage-Gated K(+) Channel HuKIII; HPCN3; HGK5; HLK3; Potassium Channel, Voltage Gated Shaker Related Subfamily A, Member 3; Voltage-Gated Potassium Channel Protein Kv1.3
- Gene ID
- 3738
- UniProt ID
- P22001
- Long Name
- Potassium Voltage-Gated Channel Subfamily A Member 3
- Sequence Similarities
- Belongs to the potassium channel family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylation promotes the cell surface expression.
Phosphorylation on Tyr-499 inhibits its channel activity.
Glycosylation at Asn279
Ubiquitination at Lys120 and Lys526
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_002223.3
- Function
- KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a potassium channel involved in regulating neuronal excitability. It plays a crucial role in action potential repolarization and is implicated in neurological disorders.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Humanized Antibody Products
IgG Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0634CL | Human Anti-KCNA3 Recombinant Antibody (TAB-0634CL) | ELISA | Humanized IgG |
| TAB-0634CL-S(P) | Human Anti-KCNA3 Recombinant Antibody; scFv Fragment (TAB-0634CL-S(P)) | ELISA | Humanized scFv |
| TAB-0634CL-F(E) | Human Anti-KCNA3 Recombinant Antibody; Fab Fragment (TAB-0634CL-F(E)) | ELISA | Humanized Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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