Recombinant Anti-KCNA3 Vesicular Antibody, EV Displayed (VS-0425-YC320)
CAT#: VS-0425-YC320
The Recombinant Anti-KCNA3 Vesicular Antibody, EV Displayed (VS-0425-YC320) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to KCNA3-expressed cells or tissues. The KCNA3 is a voltage-gated potassium channel involved in T-cell regulation and neuronal functions.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in Astrocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16625/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16625/39156_B_9_5.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000177272-KCNA3
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- KCNA3
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Potassium voltage-gated channel subfamily A member 3
- Biological Process
- Ion transport, Potassium transport, Transport
- Molecular Function
- Ion channel, Potassium channel, Voltage-gated channel
- Introduction
- Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
- Alternative Names
- HLK3, HPCN3, Kv1.3, MK3
- Gene ID
- 3738
- UniProt ID
- P22001
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "KCNA3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0634CL | Human Anti-KCNA3 Recombinant Antibody (TAB-0634CL) | ELISA | Humanized IgG |
| TAB-0634CL-S(P) | Human Anti-KCNA3 Recombinant Antibody; scFv Fragment (TAB-0634CL-S(P)) | ELISA | Humanized scFv |
| TAB-0634CL-F(E) | Human Anti-KCNA3 Recombinant Antibody; Fab Fragment (TAB-0634CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2301CT | Recombinant Mouse anti-Human KCNA3 Monoclonal antibody (FQS5599) | WB, IHC-P, IHC-Fr, ICC, IF |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY53 | Human Anti-KCNA3 scFv-Fc Chimera (VS-0325-FY53) | Inhib | Human IgG1, scFv-Fc |
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