Mouse Anti-ARG2 scFv-Fc Chimera (VS-0625-FY3) (CAT#: VS-0625-FY3)

• Immunogen
• The original antibody was obtained from naïve human scFv phage display libraries.

• Host Species
• Mouse

• Type
• Mouse IgG2a, scFv-Fc

• Specificity
• Human ARG2

• Species Reactivity
• Human, Cynomolgus monkey

• Applications
• ELISA, Inhibition

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• ELISA: 50 pg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Arginase 2; EC 3.5.3.1; Kidney-Type Arginase; Non-Hepatic Arginase; Arginase, Type II; Type II Arginase; Arginase II; EC 3.5.3;#

• Gene ID
• 384

• UniProt ID
• P78540

• Long Name
• Arginase 2

• Sequence Similarities
• Belongs to the arginase family.

• Cellular Localization
• Mitochondrion

• Post Translation Modifications
• Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• NP_001163.1

• Function
• May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis.
  Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS).
  Arginine metabolism is a critical regulator of innate and adaptive immune responses.
  Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells.
  May suppress inflammation-related signaling in asthmatic airway epithelium.
  May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity).
  In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation.

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