Anti-ARG2 Products

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For Research Use Only. Not For Clinical Use.

Uncover the precise role of Arginase 2 in cardiovascular health and cancer with Creative Biolabs' high-fidelity anti-ARG2 recombinant antibodies. A mitochondrial arginase isoform, ARG2 is pivotal in controlling nitric oxide (NO) and polyamine metabolism. The upregulation of ARG2 is linked to endothelial dysfunction and proliferative diseases. Explore the therapeutic potential of this enzyme with our exclusive research antibodies.

ARG2: A Mitochondrial Regulator of Vascular Health and Cell Growth

Arginase 2 (ARG2) is a mitochondrial enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, similar to the cytosolic arginase 1 (ARG1) enzyme. Unlike ARG1, ARG2 is expressed in extrahepatic tissues and predominantly localized in the mitochondria. In endothelial cells, ARG2 modulates NO production by competing with nitric oxide synthase (NOS) for their common substrate L-arginine. The overexpression of ARG2 in endothelial cells has been linked to reduced NO bioavailability, leading to endothelial dysfunction and contributing to the pathogenesis of diseases like atherosclerosis and pulmonary hypertension. ARG2 also plays a role in polyamine biosynthesis, which is crucial for cell proliferation and growth, a property being exploited in cancer research.

Alternative Names

Arginase 2; EC 3.5.3.1; Kidney-Type Arginase; Non-Hepatic Arginase; Arginase, Type II; Type II Arginase; Arginase II; EC 3.5.3;

Background

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.

Anti-ARG2 rAb Products

Creative Biolabs' anti-ARG2 recombinant antibodies are designed with exceptional specificity. Each antibody is validated rigorously to ensure that it does not cross-react with the ARG1 isoform. This stringent validation is essential for researchers who need to accurately study the unique function of ARG2 without interference from other arginase isoforms. We have optimized these rAbs for performance in Western Blot and IHC applications, providing you with a reagent that delivers clear and consistent results in your research.

Table 1. Featured anti-ARG2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is at the forefront of antibody development for advancing research into metabolic regulation. We use state-of-the-art production technologies to express our anti-ARG2 recombinant antibodies. These antibodies are designed to mimic the antigen recognition of the native mitochondrial enzyme, ensuring a reagent that is both specific and active for your discovery research.

Featured Anti-ARG2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ARG2 recombinant antibody production.

Fig.2 Gram-scale anti-ARG2 recombinant antibody production.

rAb Modalities

Creative Biolabs strives to be a catalyst in the research community by providing innovative and flexible antibody solutions. Our anti-ARG2 recombinant antibodies are available in a variety of modalities, which can be customized to fit the needs of your research. We enable researchers around the world to probe the specific contributions of this unique mitochondrial enzyme to disease processes.

Fig.3 Full-length anti-ARG2 recombinant antibody production and modalities.

Explore the unique contribution of the Arginase 2 isoform in cardiovascular and cancer biology with Creative Biolabs' recombinant antibodies. Our catalog of high-fidelity research antibodies are validated to provide the specificity and performance needed to drive your discoveries. Experience the Creative difference, and reach out to our team today.