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    Mouse Anti-FCMR scFv-Fc Chimera (VS-0325-FY120) (CAT#: VS-0325-FY120)

    The anti-FCMR scFv-Fc antibody targets FCMR (CD32B), an Fcγ receptor involved in immune regulation and B-cell signaling. It is useful for studying the role of FCMR in immune tolerance, autoimmunity, and B-cell biology.

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    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & focal adhesion sites.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3910/if_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3910/11162_B_8_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3910/11162_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3910/11162_A_8_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3910/11162_A_7_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3910/11162_A_6_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3910/11162_A_8_8.jpg
    Figure 8 Tonsil
    Figure 8 Tonsil
    (Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3910/11162_A_4_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Group enriched (RPMI-8226, U-266/70)
    Figure 9 RNA cell line category: Group enriched (RPMI-8226, U-266/70)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162894-FCMR

    Specifications

    • Immunogen
    • Human FcμR protein.
    • Host Species
    • Mouse
    • Type
    • Mouse IgG1, scFv-Fc
    • Specificity
    • Human FCMR
    • Species Reactivity
    • Human
    • Clone
    • HM7
    • Applications
    • Western Blot, Inhibition, Flow Cytometry

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • Flow Cytometry: 10 μg/mL

    Target

    • Alternative Names
    • Fc Fragment Of IgM Receptor; Regulator Of Fas-Induced Apoptosis Toso; Fas Apoptotic Inhibitory Molecule 3; IgM Fc Fragment Receptor; FAIM3; TOSO; Immunoglobulin Mu Fc Receptor; IgM Fc Receptor; Fc Mu Receptor
    • Long Name
    • Fc Fragment Of IgM Receptor
    • Cellular Localization
    • Cell membrane; Early endosome membrane; Golgi apparatus, trans-Golgi network membrane; Lysosome membrane
    • Post Translation Modifications
    • Phosphorylated on both Tyr and Ser residues.
      O-glycosylated.
      Sialylated.
      O-linked glycans regulate trafficking to the plasma membrane.
      Modification sites at PhosphoSitePlus
      Modification sites at neXtProt
      Glycosylation from GlyGen 2 sites, 2 O-linked glycans (2 sites)
    • Function
    • FCMR (Fc mu receptor) is a receptor that binds to IgM antibodies, playing a role in immune complex clearance and B cell signaling. It influences immune responses and is implicated in autoimmune diseases.

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    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "FCMR"

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    CAT Product Name Application Type
    TAB-153CQ Anti-Human FCMR Recombinant Antibody (A38) WB, IP
    TAB-154CQ Anti-Human FCMR Recombinant Antibody (6E9) ELISA, FC, WB
    TAB-153CQ-S(P) Anti-Human FCMR Recombinant Antibody scFv Fragment (A38) WB, IP
    TAB-154CQ-S(P) Anti-Human FCMR Recombinant Antibody scFv Fragment (6E9) ELISA, FC, WB
    TAB-153CQ-F(E) Anti-Human FCMR Recombinant Antibody Fab Fragment (A38) WB, IP

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