p62 scaffold protein anti-Human TRAF6
CAT#: SPS-L147
The p62 that bound TRAF6 was isolated from the library using phage display techonology. After affinity maturation, p62 variants were identified having affinities for TRAF6 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19805/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human rectum
Immunohistochemical staining of human rectum shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20599/48076_A_5_3_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4605/13277_A_7_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4605/13277_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4605/13277_A_8_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4605/13277_A_9_4.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4605/13277_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000175104-TRAF6
❮
❯
Specifications
- Scaffold Name
- p62
- Origin
- p62
- Target
- TRAF6
- Species Reactivity
- Human
- Expression Host
- E. coli
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for SPS-L147. Click the button above to contact us or submit your feedback about this product.
Investigating Signal Transduction
This p62 scaffold is essential for our work on signal transduction in the TNF receptor superfamily. It binds TRAF6 effectively, allowing us to study the mediation of signals from receptors like CD40 and the activation of the NF-kappaB pathway.
Confirmed TRAF-C Interaction
We validated the interaction of this protein with the TRAF-C domain using biosensor technology. It effectively links distinct signaling pathways in our cell-free assays, helping us understand the role of ubiquitin conjugating enzymes in IKK activation.
Q&As
-
What pathways does the TRAF6 target mediate?
A: TRAF6 mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. It functions as a signal transducer in the NF-kappaB pathway, activating IkappaB kinase (IKK) in response to proinflammatory cytokines.
-
What domains does the TRAF6 protein contain?
A: The TRAF6 protein has an amino terminal RING domain followed by four zinc-finger motifs, a central coiled-coil region, and a highly conserved carboxyl terminal domain known as the TRAF-C domain.
View the frequently asked questions answered by Creative Biolabs Support.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Endometrial Cancer
Throid Cancer
Maturity Onset Diabetes of the Young
Related Signaling Pathways
MAPK Signaling Pathway
TLR Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TRAF6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2456z | Mouse Anti-TRAF6 Recombinant Antibody (clone 15G1) | ELISA, WB | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2078CT | Recombinant Mouse anti-Human TRAF6 Monoclonal antibody (EML2392) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0009MZ | Recombinant Chicken Anti-TRAF6 IgY (BRD-0009MZ) | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3671 | Rabbit Anti-TRAF6 Recombinant Antibody (clone DS3671AB) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2238-CN | Rabbit Anti-TRAF6 Polyclonal Antibody (MRO-2238-CN) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1483 | Recombinant Rabbit Anti-TRAF6 Antibody (clone R05-2D6) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY1484 | Recombinant Rabbit Anti-TRAF6 Antibody (clone R09-3F4) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC934 | AbPlus™ Anti-TRAF6 Magnetic Beads (VS-0724-YC934) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2344 | Anti-TRAF6 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
-2.png)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, WB, BLI, SPR
Application: FuncS, Inhib, IP, ELISA
Application: ELISA, SPR, Inhib, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
