PE-DRB1*04:01/Human Tyrosinase (ALHIYMDGTMSQVQGSA) MHC Tetramer

CAT#: MHC-YF1115

This product is a MHC tetramer of biotinylated peptide/MHC complex composed Tyrosinase-derived peptide of ALHIYMDGTMSQVQGSA sequence covering 365-381 and DRB1*04:01 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

Specifications

  • Allele
  • DRB1*04:01
  • Class
  • Class II
  • MHC Species
  • Human
  • Antigen
  • Tyrosinase
  • Peptide
  • ALHIYMDGTMSQVQGSA
  • Range
  • 365-381
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
  • Alternative Names
  • TYR; Tyrosinase; ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
  • Gene ID
  • 7299
  • UniProt ID
  • P14679
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