Tyrosinase

Anti-Tyrosinase Products

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PE-A*02:01/Human TYR (MLLAVLYCL) MHC Tetramer (MHC-LC2226)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: MLLAVLYCL
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (YMNGTMSQV) MHC Tetramer (MHC-LC2230)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: YMNGTMSQV
- Conjugate: PE
Compare

PE-DRB1*04:01/Human TYR (NILLSNAPLGPQFP) MHC Tetramer (MHC-LC2451)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: NILLSNAPLGPQFP
- Conjugate: PE
Compare

PE-B*07:02/Human TYR (TPMFNDINI) MHC Tetramer (MHC-LC2548)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: TPMFNDINI
- Conjugate: PE
Compare

PE-DRB1*04:01/Human TYR (QNILLSNAPLGPQFP) MHC Tetramer (MHC-LC2452)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: QNILLSNAPLGPQFP
- Conjugate: PE
Compare

PE-B*51:01/Human TYR (TPMFNDINI) MHC Tetramer (MHC-LC2549)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: TPMFNDINI
- Conjugate: PE
Compare

PE-DRB1*04:01/Human TYR (SYLQDSDPDSFQD) MHC Tetramer (MHC-LC2453)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: SYLQDSDPDSFQD
- Conjugate: PE
Compare

PE-B*53:01/Human TYR (TPMFNDINI) MHC Tetramer (MHC-LC2550)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: TPMFNDINI
- Conjugate: PE
Compare

PE-DRB1*04:01/Human TYR (YLQDSDPDSFQD) MHC Tetramer (MHC-LC2454)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: YLQDSDPDSFQD
- Conjugate: PE
Compare

PE-B*51:01/Human TYR (DPDSFQDYI) MHC Tetramer (MHC-LC2464)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: DPDSFQDYI
- Conjugate: PE
Compare

PE-B*51:01/Human TYR (DPIFLLHHA) MHC Tetramer (MHC-LC2465)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: DPIFLLHHA
- Conjugate: PE
Compare

APC-A*02:01/Human TYR (MLLAVLYCL) MHC Tetramer (MHC-LC2626)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: MLLAVLYCL
- Conjugate: APC
Compare

APC-A*02:01/Human TYR (YMNGTMSQV) MHC Tetramer (MHC-LC2630)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: YMNGTMSQV
- Conjugate: APC
Compare

PE-A*02:01/Human TYR (ALLAGLVSL) MHC Tetramer (MHC-LC2901)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: ALLAGLVSL
- Conjugate: PE
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PE-A*02:01/Human TYR (ALLAGLVSLL) MHC Tetramer (MHC-LC2902)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: ALLAGLVSLL
- Conjugate: PE
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PE-A*02:01/Human TYR (AMVGAVLTA) MHC Tetramer (MHC-LC2905)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: AMVGAVLTA
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (FLLRWEQEI) MHC Tetramer (MHC-LC2909)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: FLLRWEQEI
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (FLPWHRLFL) MHC Tetramer (MHC-LC2910)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: FLPWHRLFL
- Conjugate: PE
Compare

PE-DRB1*04:01/Human TYR (ALHIYMDGTMSQVQGSA) MHC Tetramer (MHC-LC3196)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: ALHIYMDGTMSQVQGSA
- Conjugate: PE
Compare

PE-DRB1*04:04/Human TYR (ALHIYMDGTMSQVQGSA) MHC Tetramer (MHC-LC3197)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: ALHIYMDGTMSQVQGSA
- Conjugate: PE
Compare

PE-DRB1*04:01/Human TYR (ALHIYMNGTMSQVQGSA) MHC Tetramer (MHC-LC3198)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: ALHIYMNGTMSQVQGSA
- Conjugate: PE
Compare

PE-DRB1*04:04/Human TYR (ALHIYMNGTMSQVQGSA) MHC Tetramer (MHC-LC3199)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: ALHIYMNGTMSQVQGSA
- Conjugate: PE
Compare

PE-A*24:02/Human TYR (AFLPWHRLF) MHC Tetramer (MHC-LC3294)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: AFLPWHRLF
- Conjugate: PE
Compare

PE-A*01:01/Human TYR (KCDICTDEY) MHC Tetramer (MHC-LC4411)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: KCDICTDEY
- Conjugate: PE
Compare

DRB1*04:01/Human tyrosinase (ALHIYMDGTMSQVQGSA) MHC Monomer (MHC-YF056)
- Class: Class II
- Antigen: tyrosinase
- Antigen Species: Human
- Peptide: ALHIYMDGTMSQVQGSA
- Conjugate: Biotin
Compare

A*02:01/Human Tyrosinase (YMDGTMSQV) MHC Monomer (MHC-YF230)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: YMDGTMSQV
- Conjugate: Biotin
Compare

BV421-DRB1*04:01/Human Tyrosinase (ALHIYMDGTMSQVQGSA) MHC Tetramer (MHC-YF1419)
- Class: Class II
- Antigen: Tyrosinase
- Peptide: ALHIYMDGTMSQVQGSA
- Conjugate: BV421
Compare

Rabbit Anti-TYR Recombinant Antibody (clone 6B2) (ZG-0616U)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IF
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Recombinant Human Anti-Tyrosinase Soluble TCR (B12) (KIH) (VS-0622-YF5875)
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*0201
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (di111) (KIH) (VS-0622-YF5876)
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*0201
Compare

Recombinant Mouse Anti-TYR Antibody (clone 8H8-6G5-6H3) (VS3-FY1502)
- Species Reactivity: Human
- Type: Mouse IgA
- Application: IHC-P
Compare

PE-B*54:01/Human TYR (DPIFLLHHA) MHC Tetramer (MHC-LC2466)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: DPIFLLHHA
- Conjugate: PE
Compare

PE-B*07:02/Human TYR (IPLYRNGDF) MHC Tetramer (MHC-LC2482)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: IPLYRNGDF
- Conjugate: PE
Compare

PE-B*07:02/Human TYR (LPWHRLFLL) MHC Tetramer (MHC-LC2513)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: PE
Compare

PE-B*35:01/Human TYR (LPWHRLFLL) MHC Tetramer (MHC-LC2514)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: PE
Compare

PE-B*51:01/Human TYR (LPWHRLFLL) MHC Tetramer (MHC-LC2515)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: PE
Compare

PE-B*53:01/Human TYR (LPWHRLFLL) MHC Tetramer (MHC-LC2516)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: PE
Compare

PE-B*54:01/Human TYR (LPWHRLFLL) MHC Tetramer (MHC-LC2517)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: PE
Compare

PE-B*07:02/Human TYR (SPASFFSSW) MHC Tetramer (MHC-LC2533)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SPASFFSSW
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (FLPWHRLFLL) MHC Tetramer (MHC-LC2911)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: FLPWHRLFLL
- Conjugate: PE
Compare

PE-B*35:01/Human TYR (SPASFFSSW) MHC Tetramer (MHC-LC2534)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SPASFFSSW
- Conjugate: PE
Compare

PE-B*53:01/Human TYR (SPASFFSSW) MHC Tetramer (MHC-LC2535)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SPASFFSSW
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (LLAGLVSLL) MHC Tetramer (MHC-LC2919)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LLAGLVSLL
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (LLAVLYCLL) MHC Tetramer (MHC-LC2920)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LLAVLYCLL
- Conjugate: PE
Compare

DRB1*04:01/Human Tyrosinase (ALHIYMDGTMSQVQGSA) MHC Tetramer (MHC-YF811)
- Class: Class II
- Antigen: Tyrosinase
- Peptide: ALHIYMDGTMSQVQGSA
Compare

PE-A*02:01/Human TYR (LLWSFQTSA) MHC Tetramer (MHC-LC2922)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LLWSFQTSA
- Conjugate: PE
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (TA4) (C-Cys) (VS-0622-YF5206)
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*02:01
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (T43) (KIH) (VS-0622-YF5877)
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*0201
Compare

BV421-A*01:01/Human Tyrosinase (KSDICTDEY) MHC Tetramer (MHC-LC020)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: KSDICTDEY
- Conjugate: BV421
Compare

PE-B*07:02/Human TYR (IPIGTYGQM) MHC Tetramer (MHC-LC3012)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: IPIGTYGQM
- Conjugate: PE
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (KIH) (VS-0622-YF5878) (VS-0622-YF5878)
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*0201
Compare

APC-B*07:02/Human TYR (LPWHRLFLL) MHC Tetramer (MHC-LC3017)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: APC
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (TD6) (C-Cys) (VS-0622-YF5207)
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*02:01
Compare

PE-A*11:01/Human TYR (QTSAGHFPR) MHC Tetramer (MHC-LC3023)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: QTSAGHFPR
- Conjugate: PE
Compare

Recombinant Mouse Anti-Human TYR Antibody (clone U312) (MOB-0343MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC
Compare

A*02:01/Human Tyrosinase (YMDGTMSQV) MHC Tetramer (MHC-LC013)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: YMDGTMSQV
- Conjugate: BV421
Compare

PE-A*24:02/Human Tyrosinase (AFLPWHRLF) MHC Tetramer (MHC-LC155)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: AFLPWHRLF
- Conjugate: PE
Compare

PE-B*07:02/Human Tyrosinase (LPWHRLFLL) MHC Tetramer (MHC-LC015)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: PE
Compare

APC-A*24:02/Human Tyrosinase (AFLPWHRLF) MHC Tetramer (MHC-LC156)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: AFLPWHRLF
- Conjugate: APC
Compare

APC-B*07:02/Human Tyrosinase (LPWHRLFLL) MHC Tetramer (MHC-LC016)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: APC
Compare

BV421-B*07:02/Human Tyrosinase (LPWHRLFLL) MHC Tetramer (MHC-LC017)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: LPWHRLFLL
- Conjugate: BV421
Compare

PE-A*01:01/Human Tyrosinase (KSDICTDEY) MHC Tetramer (MHC-LC018)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: KSDICTDEY
- Conjugate: PE
Compare

APC-A*01:01/Human Tyrosinase (KSDICTDEY) MHC Tetramer (MHC-LC019)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: KSDICTDEY
- Conjugate: APC
Compare

A*0201/Human Tyrosinase (YMDGTMSQV) MHC Tetramer (MHC-LC791)
- Class: Class I
- Antigen: Tyrosinase
- Antigen Species: Human
- Peptide: YMDGTMSQV
Compare

Recombinant Anti-Tyr Antibody (MOB-1019)
- Derivation: Mouse
- Type: IgG
- Application: ELISA, WB, IP, FuncS
Compare

Recombinant Human Anti-Tyr Antibody (MHH-1019)
- Derivation: Human
- Type: IgG
- Application: RIA, IF, FuncS
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (UG6) (C-Cys) (VS-0622-YF5208)
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*02:01
Compare

PE-A*03:01/Human TYR (SIFEQWLRR) MHC Tetramer (MHC-LC3024)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SIFEQWLRR
- Conjugate: PE
Compare

PE-A*11:01/Human TYR (SIFEQWLRR) MHC Tetramer (MHC-LC3025)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SIFEQWLRR
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (RIWSWLLGA) MHC Tetramer (MHC-LC2927)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: RIWSWLLGA
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (VLTALLAGL) MHC Tetramer (MHC-LC2936)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: VLTALLAGL
- Conjugate: PE
Compare

PE-A*03:01/Human TYR (YMVPFIPLYR) MHC Tetramer (MHC-LC3031)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: YMVPFIPLYR
- Conjugate: PE
Compare

PE-A*02:01/Human TYR (WLLGAAMVGA) MHC Tetramer (MHC-LC2939)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: WLLGAAMVGA
- Conjugate: PE
Compare

PE-Mamu-A1*011:01/Human TYR (SEIWRDIDF) MHC Tetramer (MHC-LC3000)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SEIWRDIDF
- Conjugate: PE
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (clone B12) (scTCR-460CQ-S(P))
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*0201
Compare

PE-A*11:01/Human TYR (YMVPFIPLYR) MHC Tetramer (MHC-LC3032)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: YMVPFIPLYR
- Conjugate: PE
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (clone di111) (scTCR-461CQ-S(P))
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*0201
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (clone T43) (scTCR-462CQ-S(P))
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*0201
Compare

Recombinant Human Anti-Tyrosinase Soluble TCR (scTCR-463CQ-S(P)) (scTCR-463CQ-S(P))
- Species Reactivity: Human
- Epitope: YMDGTMSQV
- MHC: HLA-A*0201
Compare

PE-A*01:01/Human TYR (SSDYVIPIGTY) MHC Tetramer (MHC-CN1293)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SSDYVIPIGTY
- Conjugate: PE
Compare

APC-A*01:01/Human TYR (SSDYVIPIGTY) MHC Tetramer (MHC-CN1294)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SSDYVIPIGTY
- Conjugate: APC
Compare

FITC-A*01:01/Human TYR (SSDYVIPIGTY) MHC Tetramer (MHC-CN1295)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SSDYVIPIGTY
- Conjugate: FITC
Compare

A*01:01/Human TYR (SSDYVIPIGTY) MHC Tetramer (MHC-CN1296)
- Class: Class I
- Antigen: TYR
- Antigen Species: Human
- Peptide: SSDYVIPIGTY
- Conjugate: Unconjugated
Compare

APC-DRB1*04:01/Human Tyrosinase (ALHIYMDGTMSQVQGSA) MHC Tetramer (MHC-YF963)
- Class: Class II
- Antigen: Tyrosinase
- Peptide: ALHIYMDGTMSQVQGSA
- Conjugate: APC
Compare

Mouse Anti-TYR Recombinant Antibody (VS3-CJ655) (VS3-CJ655)
- Species Reactivity: Human
- Type: Mouse IgM
- Application: IHC
Compare

PE-DRB1*04:01/Human TYR (DYSYLQDSDPDSFQD) MHC Tetramer (MHC-LC3200)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: DYSYLQDSDPDSFQD
- Conjugate: PE
Compare

APC-DRB1*04:01/Human TYR (QNILLSNAPLGPQFP) MHC Tetramer (MHC-LC3213)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: QNILLSNAPLGPQFP
- Conjugate: APC
Compare

PE-DRB1*04:04/Human TYR (QNILLSNAPLGPQFP) MHC Tetramer (MHC-LC3214)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: QNILLSNAPLGPQFP
- Conjugate: PE
Compare

PE-DRB1*04:01/Human TYR (YGQMKNGSTPMFNDINIYDL) MHC Tetramer (MHC-LC3218)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: YGQMKNGSTPMFNDINIYDL
- Conjugate: PE
Compare

PE-DRB1*04:04/Human TYR (YGQMKNGSTPMFNDINIYDL) MHC Tetramer (MHC-LC3219)
- Class: Class II
- Antigen: TYR
- Antigen Species: Human
- Peptide: YGQMKNGSTPMFNDINIYDL
- Conjugate: PE
Compare

Mouse Anti-TYR Recombinant Antibody (clone ABT-TYR) (ZG-0163C)
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
Compare

Recombinant Human Anti-Tyr Antibody Fab Fragment (MHH-1019-F(E))
- Derivation: Human
- Type: Fab
- Application: ELISA, WB, FC, FuncS
Compare

Recombinant Human Anti-Tyr Antibody scFv Fragment (MHH-1019-S(P))
- Derivation: Human
- Type: scFv
- Application: WB, Neut, FuncS
Compare

Recombinant Anti-Tyr Antibody Fab Fragment (MOB-1019-F(E))
- Derivation: Mouse
- Type: Fab
- Application: RIA, WB, FuncS
Compare

Recombinant Anti-Tyr Antibody scFv Fragment (MOB-1019-S(P))
- Derivation: Mouse
- Type: scFv
- Application: ELISA, IF, FuncS
Compare

Anti-Mouse TYR Immunohistochemistry Kit (VS-0525-XY7665)
- Species Reactivity: Human, Mouse
- Target: TYR
- Application: IHC
Compare

Anti-TYR Immunohistochemistry Kit (VS-0525-XY7664)
- Species Reactivity: Human
- Target: TYR
- Application: IHC
Compare

Rabbit Anti-TYR Recombinant Antibody (clone DS3734AB) (MOR-3734)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IHC-P, WB, ICC, IF
Compare

Rabbit Anti-TYR Recombinant Antibody (VS13-YC1194) (VS13-YC1194)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
Compare

DrugMonitor™ Anti-Tyrosinase Antibody (VS-1224-YC1254) (VS-1224-YC1254)
- Specificity: Tyrosinase
- Type: Mouse IgG
- Application: ELISA, PK/PD, ADA control
Compare

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For Research Use Only. Not For Clinical Use.

Background

Tyrosinase is a multi-copper-containing, multifunctional metalloenzyme with four possible oxidation states, responsible for producing melanin pigment.

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

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