PE-HLA-A*0201/Human MART-1 (ELAGIGILTV) MHC Tetramer

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1. What is the primary use of the MHC tetramer?

   A: The PE-HLA-A*0201/MART-1 MHC tetramer is primarily used for identifying and isolating CD8+ T cells specific to the MART-1 antigen in research settings. This specificity aids researchers in studying immune responses against melanoma, facilitating breakthroughs in understanding T cell behaviors and functions.

2. Which diseases are particularly relevant to studies using this tetramer?

   A: The product is especially relevant to melanoma research, as the MART-1 antigen is frequently associated with melanoma cells. Using this tetramer, scientists can gain insights into how the immune system targets melanoma, aiding the development of related therapeutic strategies.

3. How is the tetramer labeled, and why is this important?

   A: The tetramer is labeled with phycoerythrin (PE), a fluorescent molecule. This labeling is pivotal for flow cytometry, as it allows for the visualization and quantification of specific T cell populations that interact with the MART-1 peptide presented by MHC molecules.

View the frequently asked questions answered by Creative Biolabs Support.

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