Rabbit Anti-Gab2 (phospho Y643) Antibody
CAT#: VS-0126-XL1552
Rabbit polyclonal recognizing Gab2 phosphorylated at Tyrosine 643. Targets the SHP2 recruitment site in activated signaling scaffolds; optimized for consistent results in WB and IHC.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1368/1735_G7_1_selected.jpg
Normal Tissue
Figure 2 Bone marrow
High expression in bone marrow
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/271/729_B_5_4_selected.jpg
Normal Tissue
Figure 3 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22159/50926_B_6_4_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/271/729_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22159/50926_A_8_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22159/50926_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22159/50926_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (SH-SY5Y)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000033327-GAB2
❮
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Specifications
- Host Species
- Rabbit
- Specificity
- GAB2
- Species Reactivity
- Human; Mouse; Rabbit
- Applications
- WB; IHC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Polyclonal
- Purification
- This rabbit antibody specifically binds Gab2 phosphorylated at Tyr643. Affinity purification ensures high molecular clarity, making it suitable for quantifying tyrosine kinase substrate modifications in complex signaling networks.
- Concentration
- 1.0 mg/mL
- Storage
- Store at -20˚C
- Shipping
- Ice Packs
Applications
- Application Notes
- WB: 1:500-1:1000
IHC: 1:50-1:100
Target
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Related Signaling Pathways
FcεR1 Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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