Recombinant Anti-ABCB11 Vesicular Antibody, EV Displayed (VS-0425-YC611)
CAT#: VS-0425-YC611
The Recombinant Anti-ABCB11 Vesicular Antibody, EV Displayed (VS-0425-YC611) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ABCB11-expressed cells or tissues. ABCB11 is an ABC transporter involved in multidrug resistance, functioning in bile salt export. Mutations cause progressive familial intrahepatic cholestasis, a severe liver disease.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/if_selected.jpg
Normal Tissue
Figure 2 High expression in liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_9_4.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (NB-4, RT4, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073734-ABCB11
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ABCB11
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ATP binding cassette subfamily B member 11
- Biological Process
- Lipid transport, Transport
- Molecular Function
- Translocase
- Cellular Localization
- Nucleoplasm, Plasma membrane, Cytosol
- Introduction
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
- Alternative Names
- ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP
- Gene ID
- 8647
- UniProt ID
- O95342
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Datasheet
MSDS
COA
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See other products for "ABCB11"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2146z | Mouse Anti-ABCB11 Recombinant Antibody (clone 38B10) | WB, ELISA, IF, IHC, IP | Mouse IgG2a, κ |
| HPAB-0190-CN | Human Anti-ABCB11 Recombinant Antibody (clone Batist) | WB, FC, IF | Human IgG1 |
| HPAB-0191-CN | Human Anti-ABCB11 Recombinant Antibody (clone Malimo) | WB, FC, IF | Human IgG1 |
| HPAB-0192-CN | Human Anti-ABCB11 Recombinant Antibody (clone Tweed) | WB, FC, IF | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0010 | Hi-Affi™ Rabbit Anti-ABCB11 Recombinant Antibody (clone DS10AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0190-CN-S(P) | Human Anti-ABCB11 Recombinant Antibody (clone Batist); scFv Fragment | WB, FC, IF | Human scFv |
| HPAB-0191-CN-S(P) | Human Anti-ABCB11 Recombinant Antibody (clone Malimo); scFv Fragment | WB, FC, IF | Human scFv |
| HPAB-0192-CN-S(P) | Human Anti-ABCB11 Recombinant Antibody (clone Tweed); scFv Fragment | WB, FC, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0190-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Batist); Fab Fragment | WB, FC, IF | Human Fab |
| HPAB-0191-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Malimo); Fab Fragment | WB, FC, IF | Human Fab |
| HPAB-0192-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Tweed); Fab Fragment | WB, FC, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY18 | Anti-ABCB11 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC16 | Recombinant Anti-ABCB11 (N-terminus x C-terminus) Biparatopic Antibody, Tandem scFv (Clone Batist x Clone Malimo) | FC, IF, WB | Tandem scFv |
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