Recombinant Anti-ABCB11 Vesicular Antibody, EV Displayed (VS-0425-YC611) (CAT#: VS-0425-YC611)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• ABCB11

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Rat

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• ATP binding cassette subfamily B member 11

• Biological Process
• Lipid transport, Transport

• Molecular Function
• Translocase

• Cellular Localization
• Nucleoplasm, Plasma membrane, Cytosol

• Introduction
• The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

• Alternative Names
• ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP

• Gene ID
• 8647

• UniProt ID
• O95342

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