Recombinant Anti-ABCB11 (N-terminus x C-terminus) Biparatopic Antibody, Tandem scFv (Clone Batist x Clone Malimo)
CAT#: VS-0525-YC16
The recombinant Anti-ABCB11 (N-terminus x C-terminus) biparatopic antibody, tandem scFv (Clone Batist x Clone Malimo) is designed to bind two distinct epitopes of the ABCB11 protein, known as the bile salt export pump (BSEP). This antibody utilizes a tandem scFv format, in which the Batist scFv targets the N-terminal section of BSEP, and is linked to the N-terminus of the Malimo scFv, which targets the C-terminal section.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/if_selected.jpg
Normal Tissue
Figure 2 High expression in liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_9_4.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19035/49515_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (NB-4, RT4, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073734-ABCB11
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human ABCB11
- Species Reactivity
- Human, Rat
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- Batist
- Clone 2
- Malimo
- Epitope 1
- N-terminal half of BSEP
- Epitope 2
- C-terminal half of BSEP
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- FC, IF, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- ATP Binding Cassette Subfamily B Member 11
Target
- Introduction
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
- Alternative Names
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11; Progressive Familial Intrahepatic Cholestasis 2; ATP-Binding Cassette Sub-Family B Member 11; BSEP; ABC Member 16, MDR/TAP Subfamily; Bile Salt Export Pump; Sister P-Glycoprotein; MDR/TAP Subfamily; ABC Member 16; EC 3.6.3.44; EC 3.6.3; PFIC-2; ABC16; BRIC2; PFIC2; PGY4; SPGP
- Gene ID
- 8647
- UniProt ID
- O95342
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "ABCB11"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2146z | Mouse Anti-ABCB11 Recombinant Antibody (clone 38B10) | WB, ELISA, IF, IHC, IP | Mouse IgG2a, κ |
| HPAB-0190-CN | Human Anti-ABCB11 Recombinant Antibody (clone Batist) | WB, FC, IF | Human IgG1 |
| HPAB-0191-CN | Human Anti-ABCB11 Recombinant Antibody (clone Malimo) | WB, FC, IF | Human IgG1 |
| HPAB-0192-CN | Human Anti-ABCB11 Recombinant Antibody (clone Tweed) | WB, FC, IF | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0010 | Hi-Affi™ Rabbit Anti-ABCB11 Recombinant Antibody (clone DS10AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0190-CN-S(P) | Human Anti-ABCB11 Recombinant Antibody (clone Batist); scFv Fragment | WB, FC, IF | Human scFv |
| HPAB-0191-CN-S(P) | Human Anti-ABCB11 Recombinant Antibody (clone Malimo); scFv Fragment | WB, FC, IF | Human scFv |
| HPAB-0192-CN-S(P) | Human Anti-ABCB11 Recombinant Antibody (clone Tweed); scFv Fragment | WB, FC, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0190-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Batist); Fab Fragment | WB, FC, IF | Human Fab |
| HPAB-0191-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Malimo); Fab Fragment | WB, FC, IF | Human Fab |
| HPAB-0192-CN-F(E) | Human Anti-ABCB11 Recombinant Antibody (clone Tweed); Fab Fragment | WB, FC, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC611 | Recombinant Anti-ABCB11 Vesicular Antibody, EV Displayed (VS-0425-YC611) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY18 | Anti-ABCB11 Immunohistochemistry Kit | IHC |
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