Recombinant Anti-ABCB11 (N-terminus x C-terminus) Biparatopic Antibody, Tandem scFv (Clone Batist x Clone Malimo) (CAT#: VS-0525-YC16)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human ABCB11

• Species Reactivity
• Human, Rat

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• Batist

• Clone 2
• Malimo

• Epitope 1
• N-terminal half of BSEP

• Epitope 2
• C-terminal half of BSEP

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• FC, IF, WB

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• ATP Binding Cassette Subfamily B Member 11

• Introduction
• The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

• Alternative Names
• ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11; Progressive Familial Intrahepatic Cholestasis 2; ATP-Binding Cassette Sub-Family B Member 11; BSEP; ABC Member 16, MDR/TAP Subfamily; Bile Salt Export Pump; Sister P-Glycoprotein; MDR/TAP Subfamily; ABC Member 16; EC 3.6.3.44; EC 3.6.3; PFIC-2; ABC16; BRIC2; PFIC2; PGY4; SPGP

• Gene ID
• 8647

• UniProt ID
• O95342

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