Recombinant Anti-BMPR1A Vesicular Antibody, EV Displayed (VS-0425-YC406)
CAT#: VS-0425-YC406
The Recombinant Anti-BMPR1A Vesicular Antibody, EV Displayed (VS-0425-YC406) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to BMPR1A-expressed cells or tissues. The BMPR1A is a receptor for BMPs, involved in bone formation and signaling, requiring type I and II serine/threonine kinases for function.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19398/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19398/43066_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19398/43066_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19398/43066_A_8_4.jpg
Normal Tissue
Figure 5 Testis
Peritubular cells Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19398/43066_A_4_6.jpg
Normal Tissue
Figure 6 Skeletal muscle
Myocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/19398/43066_B_2_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107779-BMPR1A
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- BMPR1A
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Bone morphogenetic protein receptor type 1A
- Molecular Function
- Kinase, Receptor, Serine/threonine-protein kinase, Transferase
- Cellular Localization
- Cytosol
- Introduction
- The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
- Alternative Names
- ACVRLK3, ALK3, CD292
- Gene ID
- 657
- UniProt ID
- P36894
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Related Signaling Pathways
TGF-β Signaling Pathway
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2969z | Mouse Anti-BMPR1A Recombinant Antibody (clone 30H4) | WB, ELISA, FC, IHC | Mouse IgG1 |
| PABL-412 | Human Anti-BMPR1A Recombinant Antibody (clone AbD1556) | FuncS | Human IgG |
| MOB-1500MZ | Recombinant Mouse Anti-Human BMPR1A Antibody | ELISA, WB | Mouse antibody |
| MRO-1698-CN | Rabbit Anti-BMPR1A Polyclonal Antibody (MRO-1698-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-XY130 | Mouse Anti-BMPR1A Recombinant Antibody (clone 4B7B2) | ELISA, WB, FC, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-409 | Human Anti-BMPR1A Recombinant Antibody (clone AbD1556); Fab Fragment | Neut, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-409 | Human Anti-BMPR1A Recombinant Antibody (clone AbD1556); scFv Fragment | Neut, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-068CQ | Mouse Anti-BMPR1A Recombinant Antibody (clone CBL674) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0371 | Hi-Affi™ Rabbit Anti-BMPR1A Recombinant Antibody (clone DS371AB) | ELISA, WB | Rabbit IgG |
| MOR-3978 | Hi-Affi™ Rabbit Anti-BMPR1A Recombinant Antibody (clone SI38DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY805 | Anti-BMPR1A Immunohistochemistry Kit | IHC |
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