Human Anti-BMPR1A Recombinant Antibody (clone AbD1556) (CAT#: PABL-412)
Recombinant Human Antibody (AbD1556) is capable of binding to BMPR-IA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-BMPR-IA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-BMPR-IA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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FuncS
Figure 1 Functional epitopes of AbD1156, AbD1564 and BMP-2.
Mutational analysis of the BMPR-IA binding epitope and in vitro interaction analysis shows that the contribution of residues within the epitope to the binding energy correlate for binding to AbD1556 and BMP-2, whereasthe two Fab AbD1556 and AbD1564 clearly bind to BMPR-IA via a different mechanism.
Harth, S., Kotzsch, A., Hu, J., Sebald, W., & Mueller, T. D. (2010). A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity. PloS one, 5(9).
FuncS
Figure 2 SPR analysis of BMPR-IA binding to BMP-2 and Fab proteins.
Sensorgram of the interaction of wild type BMPR-IA (red) and the BMPR-IA variant Q86A (blue) with AbD1556.
Harth, S., Kotzsch, A., Hu, J., Sebald, W., & Mueller, T. D. (2010). A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity. PloS one, 5(9).
Specifications
- Immunogen
- Human bone morphogenetic protein receptor, type IA
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG
- Specificity
- BMPR-IA
- Species Reactivity
- Human
- Clone
- AbD1556
- Applications
- FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Function Assay.
Target
- Alternative Names
- BMPR1A; bone morphogenetic protein receptor, type IA; ALK3; SKR5; CD292; ACVRLK3; 10q23del; bone morphogenetic protein receptor type-1A; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serinethreonine-protein kinase receptor R5
- Gene ID
- 657
- UniProt ID
- P36894
Related Resources
TGF-β Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2969z | Mouse Anti-BMPR1A Recombinant Antibody (clone 30H4) | WB, ELISA, FC, IHC | Mouse IgG1 |
| MOB-1500MZ | Recombinant Mouse Anti-Human BMPR1A Antibody | ELISA, WB | Mouse antibody |
| MRO-1698-CN | Rabbit Anti-BMPR1A Polyclonal Antibody (MRO-1698-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-XY130 | Mouse Anti-BMPR1A Recombinant Antibody (clone 4B7B2) | ELISA, WB, FC, IHC | Mouse IgG1 |
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