Human Anti-BMPR1A Recombinant Antibody (clone AbD1556) (CAT#: PABL-412)
Recombinant Human Antibody (AbD1556) is capable of binding to BMPR-IA, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-BMPR-IA mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-BMPR-IA proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Specific Inquiry
FuncS
Figure 1 Functional epitopes of AbD1156, AbD1564 and BMP-2.
Mutational analysis of the BMPR-IA binding epitope and in vitro interaction analysis shows that the contribution of residues within the epitope to the binding energy correlate for binding to AbD1556 and BMP-2, whereasthe two Fab AbD1556 and AbD1564 clearly bind to BMPR-IA via a different mechanism.
Harth, S., Kotzsch, A., Hu, J., Sebald, W., & Mueller, T. D. (2010). A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity. PloS one, 5(9).
FuncS
Figure 2 SPR analysis of BMPR-IA binding to BMP-2 and Fab proteins.
Sensorgram of the interaction of wild type BMPR-IA (red) and the BMPR-IA variant Q86A (blue) with AbD1556.
Harth, S., Kotzsch, A., Hu, J., Sebald, W., & Mueller, T. D. (2010). A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity. PloS one, 5(9).
Specifications
- Immunogen
- Human bone morphogenetic protein receptor, type IA
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG
- Specificity
- BMPR-IA
- Species Reactivity
- Human
- Clone
- AbD1556
- Applications
- FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Function Assay.
Target
- Alternative Names
- BMPR1A; bone morphogenetic protein receptor, type IA; ALK3; SKR5; CD292; ACVRLK3; 10q23del; bone morphogenetic protein receptor type-1A; ALK-3; BMPR-1A; BMP type-1A receptor; activin receptor-like kinase 3; activin A receptor, type II-like kinase 3; serinethreonine-protein kinase receptor R5
- Gene ID
- 657
- UniProt ID
- P36894
Related Resources
TGF-β Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2969z | Mouse Anti-BMPR1A Recombinant Antibody (clone 30H4) | WB, ELISA, FC, IHC | Mouse IgG1 |
| MOB-1500MZ | Recombinant Mouse Anti-Human BMPR1A Antibody | ELISA, WB | Mouse antibody |
| MRO-1698-CN | Rabbit Anti-BMPR1A Polyclonal Antibody (MRO-1698-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-XY130 | Mouse Anti-BMPR1A Recombinant Antibody (clone 4B7B2) | ELISA, WB, FC, IHC | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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