Recombinant Anti-CA12 Vesicular Antibody, EV Displayed (VS-0425-YC37)
CAT#: VS-0425-YC37
The Recombinant Anti-CA12 Vesicular Antibody, EV Displayed (VS-0425-YC37) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CA12-expressed cells or tissues. The CA12 is carbonic anhydrase 12, part of a zinc metalloenzyme family involved in diverse biological processes, including conditions like Hyperchlorhidrosis.
Gene Expression
Normal Tissue
Figure 1 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_A_9_3.jpg
Normal Tissue
Figure 2 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_A_8_5.jpg
Normal Tissue
Figure 3 Skin
Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Eccrine glands Staining: Medium Intensity: Moderate Quantity: 75%-25% Fibrohistiocytic cells Staining: Low Intensity: Weak Hair follicles Staining: Medium Intensity: Moderate Quantity: 75%-25% Sebaceous glands Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_B_4_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (A549, ASC TERT1, RT4, SK-BR-3, T-47d, U-138 MG, U-87 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000074410-CA12
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CA12
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Carbonic anhydrase 12
- Molecular Function
- Lyase
- Introduction
- Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014] CA12 (Carbonic Anhydrase 12) is a Protein Coding gene. Diseases associated with CA12 include Hyperchlorhidrosis, Isolated and Degenerative Disc Disease. Among its related pathways are Nitrogen metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14. Reversible hydration of carbon dioxide.
- Alternative Names
- HsT18816
- Gene ID
- 771
- UniProt ID
- O43570
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Datasheet
MSDS
COA
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See other products for "CA12"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-086CL | Mouse Anti-CA12 Recombinant Antibody (TAB-086CL) | IP, IF, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1958MZ | Recombinant Mouse Anti-Human CA12 Antibody | WB | Mouse antibody |
| VS-0323-CJ3 | Mouse Anti-CA12 Recombinant Antibody (clone 14D6) | ELISA, WB, FC, Inhib, FuncS | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3987 | Hi-Affi™ Rabbit Anti-CA12 Recombinant Antibody (clone SI47DS) | ELISA, IHC-P | Rabbit IgG |
| MOR-3988 | Hi-Affi™ Rabbit Anti-CA12 Recombinant Antibody (clone SI48DS) | ELISA | Rabbit IgG |
| MOR-3989 | Hi-Affi™ Rabbit Anti-CA12 Recombinant Antibody (clone SI49DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY161 | Human Anti-CA12 (clone 14D6) scFv-Fc Chimera | ELISA, WB, FC, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY289 | Anti-CA12 Immunohistochemistry Kit | IHC | |
| VS-0525-XY901 | Anti-Mouse CA12 Immunohistochemistry Kit | IHC |
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