Human Anti-CA12 (clone 14D6) scFv-Fc Chimera (CAT#: VS-0325-FY161)
This is an anti-CA XII scFv-Fc antibody derived from the monoclonal antibody 14D6. This antibody targets human CA XII, an enzyme that plays a role in tumor survival under hypoxic conditions. The scFv-Fc format combines the antigen-binding specificity of the original MAb with the potential for enhanced effector functions and longer half-life conferred by the Fc region of human IgG1.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_A_9_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_A_9_3.jpg
Figure 2 Kidney
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_A_8_5.jpg
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_A_8_5.jpg
Figure 3 Skin
(Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Eccrine glands Staining: Medium Intensity: Moderate Quantity: 75%-25% Fibrohistiocytic cells Staining: Low Intensity: Weak Hair follicles Staining: Medium Intensity: Moderate Quantity: 75%-25% Sebaceous glands Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_B_4_8.jpg
(Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity: 75%-25% Eccrine glands Staining: Medium Intensity: Moderate Quantity: 75%-25% Fibrohistiocytic cells Staining: Low Intensity: Weak Hair follicles Staining: Medium Intensity: Moderate Quantity: 75%-25% Sebaceous glands Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/25181/53836_B_4_8.jpg
Figure 4 RNA cell line category: Cell line enhanced (A549, ASC TERT1, RT4, SK-BR-3, T-47d, U-138 MG, U-87 MG)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000074410-CA12
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000074410-CA12
Specifications
- Immunogen
- Recombinant extracellular domain of human CA XII expressed in human cell line HEK-293.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human carbonic anhydrase XII (CA XII)
- Species Reactivity
- Human
- Clone
- 14D6
- Applications
- ELISA, Western Blot, Flow Cytometry, Inhibition
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Inhibition: 15 μg/mL
ELISA: 10 μg/mL
Target
- Alternative Names
- Carbonic Anhydrase 12; Carbonic Anhydrase XII; Tumor Antigen HOM-RCC-3.1.3; Carbonate Dehydratase XII; CA-XII; Carbonic Dehydratase
- Gene ID
- 771
- UniProt ID
- O43570
- Long Name
- Carbonic Anhydrase 12
- Sequence Similarities
- Belongs to the alpha-carbonic anhydrase family.
- Cellular Localization
- Cell membrane; Membrane
- Protein Refseq
- NP_001209.1; NP_996808.1
- Function
- Reversible hydration of carbon dioxide.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 14D6"
See other products for "CA12"
Select a product category from the dropdown menu below to view related products.
Please select product type
Rat Antibody Products
IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-086CL | Mouse Anti-CA12 Recombinant Antibody (TAB-086CL) | IP, IF, FC | Mouse IgG2a |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0325-FY161. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IHC, ELISA, FC, WB, ADCC, FuncS
Application: ELISA
-1.jpg)
Application: FC, FuncS, IA, IF, IP, IHC
Application: ELISA, FC, WB, Inhib, IHC
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
