Recombinant Anti-CALCR Vesicular Antibody, EV Displayed (VS-0425-YC246) (CAT#: VS-0425-YC246)
The Recombinant Anti-CALCR Vesicular Antibody, EV Displayed (VS-0425-YC246) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CALCR-expressed cells or tissues. The CALCR is a receptor for calcitonin, regulating bone resorption and associated with osteoporosis.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SuSa
(Immunofluorescent staining of human cell line SuSa shows localization to centriolar satellites, cell junctions & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/1968_E2_2_selected.jpg
(Immunofluorescent staining of human cell line SuSa shows localization to centriolar satellites, cell junctions & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/1968_E2_2_selected.jpg
Figure 2 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_6_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_6_6.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_9_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_9_4.jpg
Figure 4 Kidney
(Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_7_5.jpg
(Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_7_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (RPTEC TERT1, SuSa, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000004948-CALCR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000004948-CALCR
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CALCR
- Host Animal
- Mouse
- Antibody Isotype
- IgG2a
- Species Reactivity
- Human, Rabbit
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Calcitonin receptor
- Cellular Localization
- Cell Junctions, Vesicles, Centriolar satellite
- Introduction
- This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
- Alternative Names
- CT-R, CTR
- Gene ID
- 799
Downloads
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See other products for "CALCR"
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Intrabody Products
IgM Antibody Products
Mouse Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B017(A) | Recombinant Anti-human CALCR Intrabody [(D-Arg)9] | ELISA, IF, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B017(G) | Recombinant Anti-human CALCR Intrabody [+36 GFP] | ELISA, Neut, FuncS | scFv-(+36GFP) |
| IAB-B017(T) | Recombinant Anti-human CALCR Intrabody [Tat] | PCA, WB, FuncS | scFv-Tat |
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