Recombinant Anti-human CALCR Intrabody [Tat] (CAT#: IAB-B017(T))
Recombinant anti-CALCR intrabody in fusion with HIV Tat works within cells to bind intracellur antigen human CALCR, expressed in CHO cells. The intracellular antibody can suppresses the activity of pCRT-1 protein.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SuSa
(Immunofluorescent staining of human cell line SuSa shows localization to centriolar satellites, cell junctions & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/1968_E2_2_selected.jpg
(Immunofluorescent staining of human cell line SuSa shows localization to centriolar satellites, cell junctions & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/1968_E2_2_selected.jpg
Figure 2 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_6_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_6_6.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_9_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_9_4.jpg
Figure 4 Kidney
(Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_7_5.jpg
(Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_7_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (RPTEC TERT1, SuSa, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000004948-CALCR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000004948-CALCR
Specifications
- Immunogen
- human calcitonin receptor
- Host Species
- mouse
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Can be useful in applications such as: Protein fragment complementation; Western blot; Functional studies
Product Property
- Purity
- 95% by HPLC
- Storage
- 4 °C, -20°C if preferred
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Intrabodies
IgM Antibodies
Mouse Antibodies
IgG Antibodies
Extracellular Vesicle Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B017(A) | Recombinant Anti-human CALCR Intrabody [(D-Arg)9] | ELISA, IF, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B017(G) | Recombinant Anti-human CALCR Intrabody [+36 GFP] | ELISA, Neut, FuncS | scFv-(+36GFP) |
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