Recombinant Anti-human CALCR Intrabody [(D-Arg)9] (CAT#: IAB-B017(A))
Recombinant anti-CALCR intrabody linked to (D-Arg)9 works within cells to bind intracellur antigen human CALCR, expressed in CHO cells. The intracellular antibody can suppresses the activity of pCRT-1 protein.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SuSa
(Immunofluorescent staining of human cell line SuSa shows localization to centriolar satellites, cell junctions & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/1968_E2_2_selected.jpg
(Immunofluorescent staining of human cell line SuSa shows localization to centriolar satellites, cell junctions & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/1968_E2_2_selected.jpg
Figure 2 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_6_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_6_6.jpg
Figure 3 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_9_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_9_4.jpg
Figure 4 Kidney
(Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_7_5.jpg
(Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/61428/164612_A_7_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (RPTEC TERT1, SuSa, T-47d)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000004948-CALCR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000004948-CALCR
Specifications
- Immunogen
- human calcitonin receptor
- Host Species
- mouse
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- human
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Immunofluorescence; Neutralization; Functional studies
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- Can be stored at 4°C. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Intrabodies
IgM Antibodies
Mouse Antibodies
IgG Antibodies
Extracellular Vesicle Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B017(G) | Recombinant Anti-human CALCR Intrabody [+36 GFP] | ELISA, Neut, FuncS | scFv-(+36GFP) |
| IAB-B017(T) | Recombinant Anti-human CALCR Intrabody [Tat] | PCA, WB, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
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