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Anti-CALCR Intrabody [(D-Arg)9] (IAB-B017(A))

Recombinant anti-CALCR intrabody linked to (D-Arg)9 works within cells to bind intracellur antigen human CALCR, expressed in CHO cells. The intracellular antibody can suppresses the activity of pCRT-1 protein.      
Datasheet
Specifications
Immunogen
human calcitonin receptor
Host
mouse
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
human
Applications
Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Immunofluorescence; Neutralization; Functional studies
Target
Alternative Names
CALCR; calcitonin receptor; CRT; CTR; CT-R; CTR1
Entrez Gene ID
799
UniProt ID
P30988

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Anti-Human CALCR Therapeutic Antibody scFv Fragment (1C11)    ( TAB-1471CL-S(P) )
Anti-Human CALCR Therapeutic Antibody (31-01 (MCA 2191))    ( TAB-1473CL )
Anti-Human CALCR Therapeutic Antibody scFv Fragment (31-01 (MCA 2191))    ( TAB-1473CL-S(P) )
Recombinant Mouse Anti-Rat CALCR Antibody (clone 27/00-3G2)    ( MOB-1951MZ )
Anti-Human CALCR Therapeutic Antibody Fab Fragment (31-01 (MCA 2191))    ( TAB-1473CL-F(E) )
Recombinant Anti-human CALCR Intrabody [Tat]    ( IAB-B017(T) )
>> MORE
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