Recombinant Anti-CCR8 Vesicular Antibody, EV Displayed (VS-0425-YC46)
CAT#: VS-0425-YC46
The Recombinant Anti-CCR8 Vesicular Antibody, EV Displayed (VS-0425-YC46) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CCR8-expressed cells or tissues. The CCR8 is a chemokine receptor linked to conditions like Molluscum Contagiosum and influences signaling pathways.
Gene Expression
Normal Tissue
Figure 1 Low expression in fallopian tube
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42383/162877_A_7_7_val_selected.jpg
Normal Tissue
Figure 2 Colon
Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42383/162877_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42383/162877_A_9_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42383/162877_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000179934-CCR8
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CCR8
- Host Animal
- Rabbit
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-C motif chemokine receptor 8
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Introduction
- CCR8 (C-C Motif Chemokine Receptor 8) is a Protein Coding gene. Diseases associated with CCR8 include Molluscum Contagiosum and Kaposi Sarcoma. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR4.
- Alternative Names
- CDw198, CKR-L1, CMKBR8, CMKBRL2, CY6, GPR-CY6, TER1
- Gene ID
- 1237
- UniProt ID
- P51685
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Datasheet
MSDS
COA
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