Recombinant Anti-CR1 Vesicular Antibody, EV Displayed (VS-0425-YC567) (CAT#: VS-0425-YC567)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• CR1

• Host Animal
• Human

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 0.85 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Complement C3b/C4b receptor 1 (Knops blood group)

• Biological Process
• Complement pathway, Host-virus interaction, Immunity, Innate immunity

• Molecular Function
• Blood group antigen, Host cell receptor for virus entry, Receptor

• Cellular Localization
• Plasma membrane

• Introduction
• CR1 (Complement C3b/C4b Receptor 1 (Knops Blood Group)) is a Protein Coding gene. Diseases associated with CR1 include Malaria and Plasmodium Falciparum Malaria. Among its related pathways are Creation of C4 and C2 activators and Primary Focal Segmental Glomerulosclerosis FSGS. Gene Ontology (GO) annotations related to this gene include complement component C3b binding and complement component C4b receptor activity. An important paralog of this gene is CSMD1.

• Alternative Names
• CD35, KN

• Gene ID
• 1378

• UniProt ID
• P17927

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