Recombinant Rabbit Anti-DCX Capture Antibody (clone R34-7M-3) (CAT#: VS3-WK1824)
This antibody is a rabbit recombinant antibody against human DCX. It was developed by immunization of rabbit with recombinant human DCX protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R34-7M-3 and R16-8A-1. The clone R34-7M-3 can be used as a capture antibody in ELISA analysis to identify human DCX.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/1373_A2_4_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/1373_A2_4_selected.jpg
Figure 2 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_7_3.jpg
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_7_3.jpg
Figure 3 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_8_5.jpg
Figure 4 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_6_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_6_6.jpg
Figure 5 RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077279-DCX
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077279-DCX
Specifications
- Immunogen
- Recombinant human DCX protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human DCX
- Species Reactivity
- Human
- Clone
- R34-7M-3
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Doublecortin; Lissencephalin-X; Doublecortex; Doublin; Lis-X; DBCN; LISX
- Gene ID
- 1641
- UniProt ID
- O43602
- Long Name
- Doublecortin
- Cellular Localization
- Cell projection, Cytoplasm, Microtubule
- Post Translation Modifications
- Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity).
Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (By similarity).
- Protein Refseq
- NP_000546.2
- Function
- Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Recommended Products
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0594CT | Recombinant Mouse anti-Human DCX Monoclonal antibody (EML131) | ELISA, ICC/IF, WB | |
| MRO-0491-CN | Rabbit Anti-DCX Recombinant Antibody (clone JJ0959) | WB, FC | Rabbit IgG |
| PABS-0131 | Camelid Anti-DCX Recombinant Single Domain Antibody (Clone XA4551) | ELISA, FuncS | Camelid VHH |
| VS3-XY569 | Mouse Anti-DCX Recombinant Antibody (clone 2G5) | ELISA, WB, IHC, FC, ICC | Mouse IgG1 |
| VS3-WK1825 | Recombinant Rabbit Anti-DCX Detection Antibody (clone R16-8A-1) | ELISA | Rabbit IgG |
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