Recombinant Rabbit Anti-DCX Detection Antibody (clone R16-8A-1) (CAT#: VS3-WK1825)
This antibody is a rabbit recombinant antibody against human DCX. It was developed by immunization of rabbit with recombinant human DCX protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. R34-7M-3 and R16-8A-1 were identified as antibody pair for sandwich ELISA. As a detection antibody, the clone R16-8A-1 can be used in ELISA analysis to identify human DCX.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/1373_A2_4_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/1373_A2_4_selected.jpg
Figure 2 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_7_3.jpg
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_7_3.jpg
Figure 3 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_8_5.jpg
Figure 4 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_6_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/36121/166947_A_6_6.jpg
Figure 5 RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077279-DCX
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077279-DCX
Specifications
- Immunogen
- Recombinant human DCX protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human DCX
- Species Reactivity
- Human
- Clone
- R16-8A-1
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Doublecortin; Lissencephalin-X; Doublecortex; Doublin; Lis-X; DBCN; LISX
- Gene ID
- 1641
- UniProt ID
- O43602
- Long Name
- Doublecortin
- Cellular Localization
- Cell projection, Cytoplasm, Microtubule
- Post Translation Modifications
- Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity).
Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (By similarity).
- Protein Refseq
- NP_000546.2
- Function
- Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Recommended Products
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0594CT | Recombinant Mouse anti-Human DCX Monoclonal antibody (EML131) | ELISA, ICC/IF, WB | |
| MRO-0491-CN | Rabbit Anti-DCX Recombinant Antibody (clone JJ0959) | WB, FC | Rabbit IgG |
| PABS-0131 | Camelid Anti-DCX Recombinant Single Domain Antibody (Clone XA4551) | ELISA, FuncS | Camelid VHH |
| VS3-XY569 | Mouse Anti-DCX Recombinant Antibody (clone 2G5) | ELISA, WB, IHC, FC, ICC | Mouse IgG1 |
| VS3-WK1824 | Recombinant Rabbit Anti-DCX Capture Antibody (clone R34-7M-3) | ELISA | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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