Recombinant Anti-DSC1 Vesicular Antibody, EV Displayed (VS-0425-YC676)
CAT#: VS-0425-YC676
The Recombinant Anti-DSC1 Vesicular Antibody, EV Displayed (VS-0425-YC676) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to DSC1-expressed cells or tissues. DSC1 is a glycoprotein member of the cadherin superfamily, crucial for desmosome formation in epithelial cell adhesion, implicated in autoimmune diseases like IgA pemphigus.
Gene Expression
Normal Tissue
Figure 1 High expression in skin 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_1_val_selected.jpg
Normal Tissue
Figure 2 Low expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_3_3_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_5.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_6_6.jpg
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- DSC1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Desmocollin 1
- Biological Process
- Cell adhesion
- Introduction
- The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015]
- Alternative Names
- CDHF1
- Gene ID
- 1823
- UniProt ID
- Q08554
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Datasheet
MSDS
COA
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See other products for "DSC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3293z | Mouse Anti-DSC1 Recombinant Antibody (clone 21D11) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1051 | Hi-Affi™ Rabbit Anti-DSC1 Recombinant Antibody (clone DS1051AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0020-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0020-LSX) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0021-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0021-LSX) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0022-LSX) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0020-LSX-S(P) | Human Anti-DSC1 Recombinant Antibody; scFv Fragment (HPAB-0020-LSX-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0021-LSX-S(P) | Human Anti-DSC1 Recombinant Antibody; scFv Fragment (HPAB-0021-LSX-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022-LSX-S(P) | Human Anti-DSC1 Recombinant Antibody; scFv Fragment (HPAB-0022-LSX-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0020-LSX-F(E) | Human Anti-DSC1 Recombinant Antibody; Fab Fragment (HPAB-0020-LSX-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0021-LSX-F(E) | Human Anti-DSC1 Recombinant Antibody; Fab Fragment (HPAB-0021-LSX-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0022-LSX-F(E) | Human Anti-DSC1 Recombinant Antibody; Fab Fragment (HPAB-0022-LSX-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-XY3337 | Rabbit Anti-DSC1 Recombinant Antibody (clone R93-2A-4) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY19 | Human Anti-DSC1 scFv-Fc Chimera (VS-0425-FY19) | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2087 | Anti-DSC1 Immunohistochemistry Kit | IHC |
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