Recombinant Anti-ERBB4 Vesicular Antibody, EV Displayed (VS-0425-YC301)
CAT#: VS-0425-YC301
The Recombinant Anti-ERBB4 Vesicular Antibody, EV Displayed (VS-0425-YC301) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ERBB4-expressed cells or tissues. The ERBB4 is a member of the EGFR family with roles in cellular signaling like mitogenesis and differentiation. Mutations are linked to cancer and produce several isoforms.
Gene Expression
Normal Tissue
Figure 1 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_5.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12016/35976_A_8_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, EFO-21, HEK93, RPTEC TERT1, SCLC-21H, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000178568-ERBB4
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Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ERBB4
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Erb-b2 receptor tyrosine kinase 4
- Biological Process
- Apoptosis, Lactation, Transcription, Transcription regulation
- Molecular Function
- Activator, Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Introduction
- This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
- Alternative Names
- ALS19, HER4
- Gene ID
- 2066
- UniProt ID
- Q15303
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Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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See other products for "ERBB4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-470 | Mouse Anti-ERBB4 Recombinant Antibody (PABL-470) | WB, IF, FuncS | Mouse IgG |
| MOB-0689CT | Recombinant Mouse anti-Human ERBB4 Monoclonal antibody (I5.83.9) | FC | |
| VS3-FY513 | Recombinant Rabbit Anti-ERBB4 Antibody (clone R07-2H1) | WB | Rabbit IgG |
| VS3-XY3349 | Rabbit Anti-ERBB4 Recombinant Antibody (clone R03-6B4) | WB, ICC, IF, FC, IP | Rabbit IgG |
| VS3-WK2025 | Rabbit Anti-ERBB4 (pY1162) Recombinant Antibody (clone R07-4C0) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-467 | Mouse Anti-ERBB4 Recombinant Antibody; Fab Fragment (PFBL-467) | WB, IF, FuncS | Mouse Fab |
| HPAB-0530YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0530YY-F(E)) | ELISA | Human Fab |
| HPAB-0531YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0531YY-F(E)) | ELISA | Human Fab |
| HPAB-0532YY-F(E) | Human Anti-ERBB4 Recombinant Antibody; Fab Fragment (HPAB-0532YY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-467 | Mouse Anti-ERBB4 Recombinant Antibody; scFv Fragment (PSBL-467) | WB, IF, FuncS | Mouse scFv |
| HPAB-0530YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0530YY-S(P)) | ELISA | Human scFv |
| HPAB-0531YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0531YY-S(P)) | ELISA | Human scFv |
| HPAB-0532YY-S(P) | Human Anti-ERBB4 Recombinant Antibody; scFv Fragment (HPAB-0532YY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-073CT | Anti-Human HER4 Recombinant Antibody (HE4B-33) | ELISA, Inhibition | Human antibody |
| TAB-073CT-S(P) | Anti-Human HER4 Recombinant Antibody scFv Fragment (HE4B-33) | ELISA, Inhibition | Human antibody |
| TAB-073CT-F(E) | Anti-Human HER4 Recombinant Antibody Fab Fragment (HE4B-33) | ELISA, Inhibition | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-074CT | Mouse Anti-ERBB4 Recombinant Antibody (TAB-074CT) | ELISA, Inhibion, WB | Mouse IgG |
| TAB-074CT-S(P) | Mouse Anti-ERBB4 Recombinant Antibody; scFv Fragment (TAB-074CT-S(P)) | ELISA, Inhibion, WB | Mouse scFv |
| TAB-074CT-F(E) | Mouse Anti-ERBB4 Recombinant Antibody; Fab Fragment (TAB-074CT-F(E)) | ELISA, Inhibion, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-743CQ | Mouse Anti-ERBB4 Recombinant Antibody (clone CBL391) | Block | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-744CQ | Mouse Anti-ERBB4 Recombinant Antibody (clone CBL930) | IP, Neut, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1180 | Hi-Affi™ Rabbit Anti-ERBB4 Recombinant Antibody (clone DS1180AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF427 | A*02:01/Human ERBB-4 (VLVKSPNHV) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2339 | Anti-ERBB4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2340 | Anti-Mouse ERBB4 Immunohistochemistry Kit | IHC |
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