Recombinant Anti-FAT1 Vesicular Antibody, EV Displayed (VS-0425-YC347)
CAT#: VS-0425-YC347
The Recombinant Anti-FAT1 Vesicular Antibody, EV Displayed (VS-0425-YC347) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FAT1-expressed cells or tissues. The FAT1 is a tumor suppressor cadherin that is crucial for cell proliferation control, expressed in fetal epithelia with various transcript variants.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human rectum
Immunohistochemical staining of human rectum shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/23882/52199_A_5_3_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1869/7555_B_8_5.jpg
Normal Tissue
Figure 3 Small intestine
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1869/7834_A_6_2.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1869/7834_A_7_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (fHDF/TERT166, LHCN-M2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000083857-FAT1
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- FAT1
- Host Animal
- Mouse
- Antibody Isotype
- IgG1 kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein G
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- FAT atypical cadherin 1
- Biological Process
- Cell adhesion
- Introduction
- This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
- Alternative Names
- CDHF7, CDHR8, FAT
- Gene ID
- 2195
- UniProt ID
- Q14517
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COA
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See other products for "FAT1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4061z | Mouse Anti-FAT1 Recombinant Antibody (clone 44H5) | WB, ELISA | Mouse IgG1, κ |
| MRO-2136-CN | Rabbit Anti-FAT1 Polyclonal Antibody (MRO-2136-CN) | WB | Rabbit IgG |
| HPAB-0124-WJ | Mouse Anti-FAT1 Recombinant Antibody (HPAB-0124-WJ) | IHC, ELISA, WB | Mouse IgG2a, κ |
| VS3-WK959 | Mouse Anti-FAT1 Recombinant Antibody (VS3-WK959) | WB | Mouse IgG |
| MOB-328YC | Rabbit Anti-FAT1 Recombinant Antibody (MOB-328YC) | ELISA, FC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030WM | Anti-Human FAT1 Recombinant Antibody (198.3) | FC, WB, IHC | |
| TAB-030WM-S(P) | Anti-Human FAT1 Recombinant Antibody scFv Fragment (198.3) | WB, IHC, FC | |
| TAB-030WM-F(E) | Anti-Human FAT1 Recombinant Antibody Fab Fragment (198.3) | WB, IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0124-WJ-S(P) | Mouse Anti-FAT1 Recombinant Antibody; scFv Fragment (HPAB-0124-WJ-S(P)) | IHC, ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0124-WJ-F(E) | Mouse Anti-FAT1 Recombinant Antibody; Fab Fragment (HPAB-0124-WJ-F(E)) | IHC, ELISA, WB | Mouse Fab |
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