Recombinant Anti-FCGR2A Vesicular Antibody, EV Displayed (VS-0425-YC341)
CAT#: VS-0425-YC341
The Recombinant Anti-FCGR2A Vesicular Antibody, EV Displayed (VS-0425-YC341) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to FCGR2A-expressed cells or tissues. The FCGR2A is a low-affinity Fc receptor involved in phagocytosis and immune complex clearance.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10776/1926_F1_3_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong positivity in endothelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14730/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10776/1847_F1_2_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10718/26353_B_4_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HEL, HMC-1, K-562, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143226-FCGR2A
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- FCGR2A
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Fc gamma receptor IIa
- Biological Process
- Immunity
- Molecular Function
- IgG-binding protein, Receptor
- Cellular Localization
- Plasma membrane, Golgi apparatus
- Introduction
- This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
- Alternative Names
- CD32, CD32A, CDw32, Fc-gamma-RIIa, FCG2, FcgammaRIIa, FCGR2, FCGR2A1, IGFR2
- Gene ID
- 2212
- UniProt ID
- P12318
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Datasheet
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