Recombinant Rabbit Anti-GAP43 Capture Antibody (clone R39-2C-4)
CAT#: VS3-WK1840
This antibody is a rabbit recombinant antibody against human GAP43. It was developed by immunization of rabbit with recombinant human GAP43 protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R81-6N-1 and R39-2C-4. The clone R39-2C-4 can be used as a capture antibody in ELISA analysis to identify human GAP43.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Immunofluorescent staining of human cell line SH-SY5Y shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13392/1510_B4_2_selected.jpg
Normal Tissue
Figure 2 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15600/35117_A_8_3.jpg
Normal Tissue
Figure 3 High expression in cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15600/35117_B_9_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172020-GAP43
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Specifications
- Immunogen
- Recombinant human GAP43 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human GAP43
- Species Reactivity
- Human
- Clone
- R39-2C-4
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Growth Associated Protein 43; Axonal Membrane Protein GAP-43; Neural Phosphoprotein B-50; Neuron Growth-Associated Protein 43; Nerve Growth-Related Peptide GAP43; Calmodulin-Binding Protein P-57
- Gene ID
- 2596
- UniProt ID
- P17677
- Long Name
- Growth Associated Protein 43
- Sequence Similarities
- Belongs to the neuromodulin family.
- Cellular Localization
- Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse
- Post Translation Modifications
- Phosphorylated (By similarity).
Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Palmitoylated by ZDHHC3 (By similarity).
Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216).
Deacylated by LYPLA2 (PubMed:21152083).
- Protein Refseq
- NP_001123536.1; NP_002036.1
- Function
- This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Detection antibody
Isotype Control
- CAT
- Product Name
Secondary Antibody
See other products for "GAP43"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1629z | Mouse Anti-GAP43 Recombinant Antibody (clone 29G1) | WB, ICC, IF, IHC | Mouse IgG1 |
| MRO-0629-CN | Rabbit Anti-GAP43 Recombinant Antibody (clone CBACN-234) | WB, IF, IHC, IP, FC | Rabbit IgG |
| MRO-1882-CN | Rabbit Anti-GAP43 Polyclonal Antibody (MRO-1882-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-WK1360 | Mouse Anti-GAP43 Recombinant Antibody (VS3-WK1360) | WB, IF, IHC-P | Mouse IgG |
| VS3-WK1841 | Recombinant Rabbit Anti-GAP43 Detection Antibody (clone R81-6N-1) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0698MZ | Chicken Anti-Gap43 Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1397 | Hi-Affi™ Rabbit Anti-GAP43 Recombinant Antibody (clone DS1397AB) | WB, IP, ICC, FC, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC684 | AbPlus™ Anti-GAP43 Magnetic Beads (VS-0724-YC684) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2725 | Anti-GAP43 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2726 | Anti-Mouse GAP43 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2727 | Anti-Rat GAP43 Immunohistochemistry Kit | IHC |
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