Recombinant Anti-HLA-B Vesicular Antibody, EV Displayed (VS-0425-YC698)
CAT#: VS-0425-YC698
The Recombinant Anti-HLA-B Vesicular Antibody, EV Displayed (VS-0425-YC698) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to HLA-B-expressed cells or tissues. HLA-B belongs to the HLA class I heavy chain paralogues, playing a key role in immune response by presenting peptides on nearly all cells.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15418/35903_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endocrine cells
Staining: High
Intensity: Strong
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15418/35903_A_8_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15418/35903_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15418/35903_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
Preleptotene spermatocytes
Staining: High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15418/35903_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15418/35903_A_9_8.jpg
Normal Tissue
Figure 7 Spleen
Cells in red pulp
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in white pulp
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15418/35903_B_9_4.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (A-431, EFO-21, U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000234745-HLA-B
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- HLA-B
- Host Animal
- Rabbit
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Major histocompatibility complex, class I, B
- Biological Process
- Adaptive immunity, Host-virus interaction, Immunity, Innate immunity
- Introduction
- HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
- Alternative Names
- AS
- Gene ID
- 3106
- UniProt ID
- P01889
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Datasheet
MSDS
COA
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| MOB-1156z | Mouse Anti-HLA-B Recombinant Antibody (clone 41D6) | IHC, WB, IP, FuncS | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
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| MOB-2308MZ | Recombinant Mouse Anti-Human HLA-B Antibody (clone FQ-5) | ICC | Mouse antibody |
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| CAT | Product Name | Application | Type |
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| MHC-LC1972 | PE-B7/Human HLA-B (LVMAPRTVL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3359 | PE-DRB1*13:01/Human HLA-B (GPDGRLLRGHDQYAYDGKDY) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3360 | PE-DRB1*13:01/Human HLA-B (GPDGRLLRGHDQYAYDGKD) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3380 | PE-H2-Kd/Human HLA-B (RYLENGKETLQRA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3381 | APC-H2-Kd/Human HLA-B (RYLENGKETLQRA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FN-182CQ | Mouse Anti-HLA-B Recombinant Antibody (VMC212) | FC, FuncS | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1475CQ | Rabbit Anti-HLA-B Recombinant Antibody (clone YTH 76.3) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX532 | Mouse Anti-HLA-B Recombinant Antibody (clone 11C3) | WB, ICC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX534 | Mouse Anti-HLA-B Recombinant Antibody (clone 528CT10.4.1) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3165 | Anti-HLA-B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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