Recombinant Anti-ITGB7 Vesicular Antibody, EV Displayed (VS-0425-YC329)
CAT#: VS-0425-YC329
The Recombinant Anti-ITGB7 Vesicular Antibody, EV Displayed (VS-0425-YC329) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ITGB7-expressed cells or tissues. The ITGB7 is an integrin beta chain forming dimers for leukocyte adhesion, supporting lymphocyte migration and epithelial cadherin binding.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42277/476_E12_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139626-ITGB7
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ITGB7
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Integrin subunit beta 7
- Biological Process
- Cell adhesion
- Molecular Function
- Host cell receptor for virus entry, Integrin, Receptor
- Cellular Localization
- Plasma membrane, Cytosol
- Introduction
- This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
- Gene ID
- 3695
- UniProt ID
- P26010
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| TAB-0578CL | Human Anti-ITGB7 Recombinant Antibody (TAB-0578CL) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
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| TAB-0578CL-S(P) | Human Anti-ITGB7 Recombinant Antibody; scFv Fragment (TAB-0578CL-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0578CL-F(E) | Human Anti-ITGB7 Recombinant Antibody; Fab Fragment (TAB-0578CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
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| BRD-0302MZ | Chicken Anti-ITGB7 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
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| NEUT-1604CQ | Recombinant Rat Anti-Itgb7 Antibody (FIB27) | FC, IP, BL | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1605CQ | Recombinant Rat Anti-Itgb7 Antibody (FIB504) | FC, BL | IgG2a, κ |
| CAT | Product Name | Application | Type |
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| NEUT-1606CQ | Recombinant Rat Anti-Itgb7 Antibody (MAB0841) | BL, FC, IHC-Fr, IP | IgG2 |
| CAT | Product Name | Application | Type |
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| MOR-1888 | Hi-Affi™ Recombinant Rabbit Anti-ITGB7 Monoclonal Antibody (DS1888AB) | ICC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY780 | Recombinant Mouse Anti-ITGB7 Antibody (clone 4C6B4H9) | ELISA, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY135 | Human Anti-ITGB7 scFv-Fc Chimera (VS-0425-FY135) | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| VS7-0425-WR163 | Mouse Anti-ITGB7 Recombinant Antibody (clone 6A2G4) | IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| VS7-0425-WR164 | Mouse Anti-ITGB7 Recombinant Antibody (clone 4C5D2) | IHC, ICC, FC | Mouse IgG1 |
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| VS7-0425-WR165 | Mouse Anti-ITGB7 Recombinant Antibody (clone 1B4A8) | IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3668 | Anti-Mouse ITGB7 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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