Recombinant Anti-LINGO1 Vesicular Antibody, EV Displayed (VS-0425-YC311)
CAT#: VS-0425-YC311
The Recombinant Anti-LINGO1 Vesicular Antibody, EV Displayed (VS-0425-YC311) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LINGO1-expressed cells or tissues. The LINGO1 binds EGFR and negatively regulates neuronal processes, associated with intellectual disability and glaucoma.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1466_F12_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1595_E7_2_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1521_F12_2_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, AN3-CA, HAP1, HEK93, MCF7, NTERA-2, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169783-LINGO1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LINGO1
- Host Animal
- Human
- Antibody Isotype
- IgG4
- Species Reactivity
- Human, Cynomolgus, Rat
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 1.84 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Leucine rich repeat and Ig domain containing 1
- Cellular Localization
- Plasma membrane
- Introduction
- Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within negative regulation of oligodendrocyte differentiation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neuron development. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma.
- Alternative Names
- FLJ14594, LERN1, LRRN6A
- Gene ID
- 84894
- UniProt ID
- Q96FE5
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "LINGO1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1666-VHH | Recombinant Anti-Human LINGO1 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-632 | Human Anti-LINGO1 Recombinant Antibody (PABL-632) | ELISA | Human IgG |
| PABL-633 | Human Anti-LINGO1 Recombinant Antibody (PABL-633) | WB, IF, FuncS | Human IgG |
| HPAB-1576-FY | Human Anti-LINGO1 Recombinant Antibody (HPAB-1576-FY) | WB, ELISA, IF | Human IgG |
| HPAB-1577-FY | Human Anti-LINGO1 Recombinant Antibody (HPAB-1577-FY) | WB, ELISA, IF | Human IgG |
| HPAB-1578-FY | Human Anti-LINGO1 Recombinant Antibody (HPAB-1578-FY) | WB, ELISA, IF | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-627 | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (PFBL-627) | ELISA | Human Fab |
| PFBL-628 | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (PFBL-628) | WB, IF, FuncS | Human Fab |
| HPAB-1292-FY-S(P) | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (HPAB-1292-FY-S(P)) | WB, ELISA | Human scFv |
| HPAB-1576-FY-S(P) | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (HPAB-1576-FY-S(P)) | WB, ELISA, IF | Human scFv |
| HPAB-1577-FY-S(P) | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (HPAB-1577-FY-S(P)) | WB, ELISA, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-627 | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (PSBL-627) | ELISA | Human scFv |
| PSBL-628 | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (PSBL-628) | WB, IF, FuncS | Human scFv |
| HPAB-1292-FY-F(E) | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (HPAB-1292-FY-F(E)) | WB, ELISA | Human Fab |
| HPAB-1576-FY-F(E) | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (HPAB-1576-FY-F(E)) | WB, ELISA, IF | Human Fab |
| HPAB-1577-FY-F(E) | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (HPAB-1577-FY-F(E)) | WB, ELISA, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0681CL | Anti-Human LINGO1 Recombinant Antibody (4784) | ELISA, FC | Human antibody |
| TAB-0682CL | Anti-Human LINGO1 Recombinant Antibody (4785) | ELISA, FC | Human antibody |
| TAB-0681CL-S(P) | Anti-Human LINGO1 Recombinant Antibody scFv Fragment (4784) | ELISA, FC | Human antibody |
| TAB-0681CL-F(E) | Anti-Human LINGO1 Recombinant Antibody Fab Fragment (4784) | ELISA, FC | Human antibody |
| TAB-0682CL-F(E) | Anti-Human LINGO1 Recombinant Antibody Fab Fragment (4785) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY142 | Human Anti-LINGO1 (clone 4784) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
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