Recombinant Anti-LINGO1 Vesicular Antibody, EV Displayed (VS-0425-YC311) (CAT#: VS-0425-YC311)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• LINGO1

• Host Animal
• Human

• Antibody Isotype
• IgG4

• Species Reactivity
• Human, Cynomolgus, Rat

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• z domain

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Binding Affinity
• Kd = 1.84 µg/mL

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Leucine rich repeat and Ig domain containing 1

• Cellular Localization
• Plasma membrane

• Introduction
• Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within negative regulation of oligodendrocyte differentiation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neuron development. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma.

• Alternative Names
• FLJ14594, LERN1, LRRN6A

• Gene ID
• 84894

• UniProt ID
• Q96FE5

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