Human Anti-LINGO1 (clone 4784) scFv-Fc Chimera
CAT#: VS-0425-FY142
The anti-LINGO1 scFv-FC is designed to specifically target LINGO1, a neuronal protein implicated in inhibiting axonal regeneration and remyelination. By fusing a single-chain variable fragment to the Fc region, this product leverages enhanced stability and potential therapeutic modulation of LINGO1 activity. Its applications are particularly relevant in neurobiology and regenerative medicine, providing a mechanism to explore and potentially overcome barriers to nerve repair and recovery in conditions such as multiple sclerosis and spinal cord injury.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1466_F12_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1595_E7_2_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1521_F12_2_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, AN3-CA, HAP1, HEK93, MCF7, NTERA-2, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169783-LINGO1
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human LINGO1
- Species Reactivity
- Human, Cynomolgus, Rat
- Clone
- 4784
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Essential Tremor
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Leucine Rich Repeat And Ig Domain Containing 1 2 3 5Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1 3 4Leucine-Rich Repeat Neuronal Protein 1 3 4Leucine Rich Repeat Neuronal 6A 2 3LRRN6A 3 4LERN1 3 4Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 3Leucine-Rich Repeat Neuronal Protein 6A 4UNQ201 3
- Gene ID
- 84894
- UniProt ID
- Q96FE5
- Long Name
- Leucine Rich Repeat And Ig Domain Containing 1
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated.
Contains predominantly high-mannose glycans.
Glycosylation at Asn144, Asn202, Asn264, Asn274, Asn293, Asn341, Asn492, Asn505, Asn526, and Asn542
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect LIGO1_HUMAN (1450)
Glycosylation from GlyGen 10 sites, 3 N-linked glycans (3 sites)
- Protein Refseq
- XP_011520420.1; XP_016878171.1; XP_024305859.1; XP_054234980.1; XP_054234981.1
- Function
- Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors.
Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 4784"
- CAT
- Product Name
See other products for "LINGO1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1666-VHH | Recombinant Anti-Human LINGO1 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-632 | Human Anti-LINGO1 Recombinant Antibody (PABL-632) | ELISA | Human IgG |
| PABL-633 | Human Anti-LINGO1 Recombinant Antibody (PABL-633) | WB, IF, FuncS | Human IgG |
| HPAB-1576-FY | Human Anti-LINGO1 Recombinant Antibody (HPAB-1576-FY) | WB, ELISA, IF | Human IgG |
| HPAB-1577-FY | Human Anti-LINGO1 Recombinant Antibody (HPAB-1577-FY) | WB, ELISA, IF | Human IgG |
| HPAB-1578-FY | Human Anti-LINGO1 Recombinant Antibody (HPAB-1578-FY) | WB, ELISA, IF | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-627 | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (PFBL-627) | ELISA | Human Fab |
| PFBL-628 | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (PFBL-628) | WB, IF, FuncS | Human Fab |
| HPAB-1576-FY-S(P) | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (HPAB-1576-FY-S(P)) | WB, ELISA, IF | Human scFv |
| HPAB-1577-FY-S(P) | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (HPAB-1577-FY-S(P)) | WB, ELISA, IF | Human scFv |
| HPAB-1578-FY-S(P) | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (HPAB-1578-FY-S(P)) | WB, ELISA, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-627 | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (PSBL-627) | ELISA | Human scFv |
| PSBL-628 | Human Anti-LINGO1 Recombinant Antibody; scFv Fragment (PSBL-628) | WB, IF, FuncS | Human scFv |
| HPAB-1576-FY-F(E) | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (HPAB-1576-FY-F(E)) | WB, ELISA, IF | Human Fab |
| HPAB-1577-FY-F(E) | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (HPAB-1577-FY-F(E)) | WB, ELISA, IF | Human Fab |
| HPAB-1578-FY-F(E) | Human Anti-LINGO1 Recombinant Antibody; Fab Fragment (HPAB-1578-FY-F(E)) | WB, ELISA, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0681CL | Anti-Human LINGO1 Recombinant Antibody (4784) | ELISA, FC | Human antibody |
| TAB-0681CL-S(P) | Anti-Human LINGO1 Recombinant Antibody scFv Fragment (4784) | ELISA, FC | Human antibody |
| TAB-0682CL-S(P) | Anti-Human LINGO1 Recombinant Antibody scFv Fragment (4785) | ELISA, FC | Human antibody |
| TAB-0681CL-F(E) | Anti-Human LINGO1 Recombinant Antibody Fab Fragment (4784) | ELISA, FC | Human antibody |
| TAB-0682CL-F(E) | Anti-Human LINGO1 Recombinant Antibody Fab Fragment (4785) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC311 | Recombinant Anti-LINGO1 Vesicular Antibody, EV Displayed (VS-0425-YC311) | ELISA, FC, Cell-uptake |
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