Human Anti-LINGO1 (clone 4784) scFv-Fc Chimera (CAT#: VS-0425-FY142)
The anti-LINGO1 scFv-FC is designed to specifically target LINGO1, a neuronal protein implicated in inhibiting axonal regeneration and remyelination. By fusing a single-chain variable fragment to the Fc region, this product leverages enhanced stability and potential therapeutic modulation of LINGO1 activity. Its applications are particularly relevant in neurobiology and regenerative medicine, providing a mechanism to explore and potentially overcome barriers to nerve repair and recovery in conditions such as multiple sclerosis and spinal cord injury.
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1466_F12_2_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1466_F12_2_selected.jpg
Figure 2 IF staining of human cell line AF22
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1595_E7_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1595_E7_2_blue_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1521_F12_2_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74653/1521_F12_2_blue_red_green.jpg
Figure 4 RNA cell line category: Cell line enhanced (AF22, AN3-CA, HAP1, HEK93, MCF7, NTERA-2, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169783-LINGO1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169783-LINGO1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human LINGO1
- Species Reactivity
- Human, Cynomolgus, Rat
- Clone
- 4784
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Essential Tremor
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Leucine Rich Repeat And Ig Domain Containing 1 2 3 5Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1 3 4Leucine-Rich Repeat Neuronal Protein 1 3 4Leucine Rich Repeat Neuronal 6A 2 3LRRN6A 3 4LERN1 3 4Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 3Leucine-Rich Repeat Neuronal Protein 6A 4UNQ201 3
- Gene ID
- 84894
- UniProt ID
- Q96FE5
- Long Name
- Leucine Rich Repeat And Ig Domain Containing 1
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated.
Contains predominantly high-mannose glycans.
Glycosylation at Asn144, Asn202, Asn264, Asn274, Asn293, Asn341, Asn492, Asn505, Asn526, and Asn542
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect LIGO1_HUMAN (1450)
Glycosylation from GlyGen 10 sites, 3 N-linked glycans (3 sites)
- Protein Refseq
- XP_011520420.1; XP_016878171.1; XP_024305859.1; XP_054234980.1; XP_054234981.1
- Function
- Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors.
Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single Domain Antibody Products
Fab Antibody Products
ScFv Antibody Products
Human Antibody Products
IgG Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1666-VHH | Recombinant Anti-Human LINGO1 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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