Recombinant Anti-LRP5 Vesicular Antibody, EV Displayed (VS-0425-YC577)
CAT#: VS-0425-YC577
The Recombinant Anti-LRP5 Vesicular Antibody, EV Displayed (VS-0425-YC577) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LRP5-expressed cells or tissues. LRP5 is a transmembrane receptor involved in endocytosis and Wnt protein signaling, playing a key role in skeletal homeostasis. Mutations in LRP5 can cause bone density-related diseases and familial exudative vitreoretinopathy.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human liver
Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/30505/137915_A_7_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13001/33336_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13001/33336_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13001/33336_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13001/33336_A_4_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13001/33336_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162337-LRP5
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LRP5
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- LDL receptor related protein 5
- Biological Process
- Endocytosis, Wnt signaling pathway
- Molecular Function
- Developmental protein, Receptor
- Introduction
- This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
- Alternative Names
- BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2
- Gene ID
- 4041
- UniProt ID
- O75197
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Related Signaling Pathways
Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Hepatocellular Carcinoma
Pancreatic Cancer
Throid Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
| MOB-632-S(P) | Recombinant Anti-human LRP5 Antibody scFv Fragment | FC, ELISA, FuncS | scFv |
| MHH-632-S(P) | Recombinant Human Anti-human LRP5 Antibody scFv Fragment | FC, WB, FuncS | scFv |
| HPAB-0345-YC-S(P) | Human Anti-LRP5 Recombinant Antibody; scFv Fragment (HPAB-0345-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-AP374-YC-S(P) | Human Anti-LRP5 Recombinant Antibody; scFv Fragment (HPAB-AP374-YC-S(P)) | ELISA | Human scFv |
| HPAB-AP375-YC-S(P) | Human Anti-LRP5 Recombinant Antibody; scFv Fragment (HPAB-AP375-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0702CL | Human Anti-LRP5 Recombinant Antibody (TAB-0702CL) | ELISA | Human IgG1 |
| TAB-0702CL-S(P) | Human Anti-LRP5 Recombinant Antibody; scFv Fragment (TAB-0702CL-S(P)) | ELISA | Human scFv |
| TAB-0702CL-F(E) | Human Anti-LRP5 Recombinant Antibody; Fab Fragment (TAB-0702CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP374-YC | Human Anti-LRP5 Recombinant Antibody (HPAB-AP374-YC) | ELISA | Human IgG |
| HPAB-AP375-YC | Human Anti-LRP5 Recombinant Antibody (HPAB-AP375-YC) | ELISA | Human IgG |
| HPAB-AP376-YC | Human Anti-LRP5 Recombinant Antibody (HPAB-AP376-YC) | ELISA | Human IgG |
| HPAB-AP377-YC | Human Anti-LRP5 Recombinant Antibody (HPAB-AP377-YC) | ELISA | Human IgG |
| HPAB-AP378-YC | Human Anti-LRP5 Recombinant Antibody (HPAB-AP378-YC) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP374-YC-F(E) | Human Anti-LRP5 Recombinant Antibody; Fab Fragment (HPAB-AP374-YC-F(E)) | ELISA | Human Fab |
| HPAB-AP375-YC-F(E) | Human Anti-LRP5 Recombinant Antibody; Fab Fragment (HPAB-AP375-YC-F(E)) | ELISA | Human Fab |
| HPAB-AP376-YC-F(E) | Human Anti-LRP5 Recombinant Antibody; Fab Fragment (HPAB-AP376-YC-F(E)) | ELISA | Human Fab |
| HPAB-AP377-YC-F(E) | Human Anti-LRP5 Recombinant Antibody; Fab Fragment (HPAB-AP377-YC-F(E)) | ELISA | Human Fab |
| HPAB-AP378-YC-F(E) | Human Anti-LRP5 Recombinant Antibody; Fab Fragment (HPAB-AP378-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4099 | Anti-LRP5 Immunohistochemistry Kit | IHC |
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