Recombinant Mouse Anti-NOS2 Antibody (clone 2H6B10) (CAT#: VS4-CJ56)
This mouse anti-NOS2 antibody (clone 2H6B10) is a product that recognizes human NOS2. The immunogen of this antibody is recombinant human Nitric oxide synthase, inducible protein (1aa-200aa). This product was purified by protein G purified and it has been tested for use in ELISA, Western Blot (1:1000-1:5000), Flow Cytometry (1:50-1:200).
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2014/166726_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2014/166726_B_8_5.jpg
Figure 2 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2014/166726_A_9_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2014/166726_A_9_4.jpg
Figure 3 RNA cell line category: Group enriched (CACO-2, SCLC-21H)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000007171-NOS2
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000007171-NOS2
Specifications
- Immunogen
- Recombinant Human Nitric oxide synthase, inducible protein (1aa-200aa)
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human NOS2
- Species Reactivity
- Human
- Clone
- 2H6B10
- Applications
- ELISA, WB, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, PBS, pH 7.3.
- Preservative
- 0.1% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:1000-1:5000), Flow Cytometry (1:50-1:200).
Target
- Alternative Names
- NOS; INOS; NOS2A; HEP-NOS
- Gene ID
- 4843
- UniProt ID
- P35228
- Long Name
- Nitric oxide synthase 2
- Sequence Similarities
- Belongs to the NOS family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
- Protein Refseq
- NP_000616.3
- Function
- Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004, PubMed:7682706, PubMed:7504305).
In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity).
As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112).
Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109).
Recommended Products
Secondary Antibody
Recommended Dilution Buffer
Related Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1473z | Mouse Anti-NOS2 Recombinant Antibody (clone 26B5) | WB, ELISA, FC, IF, IHC, IP | Mouse IgG1, κ |
| MOB-2264MZ | Recombinant Mouse Anti-Mouse NOS2 Antibody (clone OPT-JO) | ICC/IF, WB | Mouse antibody |
| MRO-1976-CN | Rabbit Anti-NOS2 Polyclonal Antibody (MRO-1976-CN) | IF, IHC, FC, WB | Rabbit IgG |
| VS3-XY1171 | Mouse Anti-NOS2 Recombinant Antibody (clone 4E5) | ELISA, WB, IHC, FC | Mouse IgG1 |
| VS3-XY3449 | Rabbit Anti-NOS2 Recombinant Antibody (clone R05-6G2) | WB, ICC, IF, IP | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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