Recombinant Rabbit Anti-NUF2 Antibody (clone 8B7) (CAT#: VS4-CJ63)
This rabbit anti-NUF2 antibody (clone 8B7) is a product that recognizes human NUF2. The immunogen of this antibody is a synthesized peptide derived from human NUF2. The mAb has been tested for use in ELISA, Western Blot (1:500-1:2000).
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59692/1005_B10_1_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59692/1005_B10_1_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76604/1899_E6_32_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76604/1899_E6_32_selected.jpg
Figure 3 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143228-NUF2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143228-NUF2
Specifications
- Immunogen
- A synthesized peptide derived from human NUF2
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human NUF2
- Species Reactivity
- Human
- Clone
- 8B7
- Applications
- ELISA, WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 150 mM NaCl, PBS, pH 7.4.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:2000).
Target
- Alternative Names
- CDCA1; CT106; NUF2R; hNuf2; hNuf2R; hsNuf2; Cell division cycle-associated protein 1
- Gene ID
- 83540
- UniProt ID
- Q9BZD4
- Long Name
- NUF2 component of NDC80 kinetochore complex
- Sequence Similarities
- Belongs to the NUF2 family.
- Cellular Localization
- Centromere, Chromosome, Kinetochore, Nucleus
- Post Translation Modifications
- Can be phosphorylated by AURKA and AURKB.
- Protein Refseq
- NP_113611.2; NP_663735.2
- Function
- Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2518 | Hi-Affi™ Recombinant Rabbit Anti-NUF2 Monoclonal Antibody (DS2518AB) | WB, FC | IgG |
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