Recombinant Anti-OLR1 Vesicular Antibody, EV Displayed (VS-0425-YC309)

CAT#: VS-0425-YC309

The Recombinant Anti-OLR1 Vesicular Antibody, EV Displayed (VS-0425-YC309) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to OLR1-expressed cells or tissues. The OLR1 is a lectin receptor involved in LDL binding and degradation, linked to apoptosis regulation and cardiovascular diseases.

Gene Expression
Figure 1 IF staining of human cell line A-431 Figure 2 RNA cell line category: Cell line enhanced (CACO-2, HaCaT, HHSteC, hTCEpi, SiHa, SK-BR-3)

Recombinant Antibody

  • Application
  • ELISA, FC, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • OLR1
  • Host Animal
  • Mouse
  • Antibody Isotype
  • IgG
  • Species Reactivity
  • Human, Macaque
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • Protein A
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Oxidized low density lipoprotein receptor 1
  • Biological Process
  • Cell adhesion, Immunity, Inflammatory response
  • Molecular Function
  • Receptor
  • Cellular Localization
  • Nucleoplasm, Plasma membrane, Vesicles
  • Introduction
  • This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
  • Alternative Names
  • CLEC8A, LOX-1, SCARE1
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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