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OLR1
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Protein class
Disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Macrophages, Hofbauer cells)
Immune cell specificity
Immune cell enhanced (myeloid DC)
Cell line specificity
Cell line enhanced (CACO-2, HaCaT, HHSteC, hTCEpi, SiHa, SK-BR-3)
Interaction
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70. (Microbial infection) Binds to the head and beginning of the coiled stalk of N. meningitidis adhesin A (nadA) variant 3; binding can be abrogated by monoclonal antibodies against the specific regions of NadA. Binding occurs in protein microarrays, in solution and when LOX-1 is expressed on the cell surface.
Molecular function
Receptor
More Types Infomation
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- Species Reactivity: Cynomolgus
- Type: IgG
- Application: ELISA
- Rabbit Anti-OLR1 Polyclonal Antibody (MRO-2014-CN) (MRO-2014-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
- Mouse Anti-OLR1 Recombinant Antibody (clone 6H3) (MOB-2198z)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, IF, FuncS
- Recombinant Mouse Anti-OLR1 Antibody (CBL368) (NEUT-1812CQ)
-
- Species Reactivity: Human
- Type: IgG2b
- Application: BL, WB, FC, CyTOF
- Recombinant Mouse Anti-OLR1 Antibody (CBL369) (NEUT-1813CQ)
-
- Species Reactivity: Human
- Type: IgG1
- Application: BL
- Mouse Anti-OLR1 Recombinant Antibody (clone 23C11) (MOR-0024-FY)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: FC, FuncS, IF
- Recombinant Mouse Anti-OLR1 Antibody (CBL137) (NEUT-1809CQ)
-
- Species Reactivity: Human
- Type: IgG1
- Application: Neut, WB
- Recombinant Mouse Anti-OLR1 Antibody (CBL915) (NEUT-1810CQ)
-
- Species Reactivity: Human
- Type: IgG1
- Application: FC, Neut
- Recombinant Mouse Anti-OLR1 Antibody (CBL916) (NEUT-1811CQ)
-
- Species Reactivity: Human, Mouse
- Type: IgG1
- Application: FC, IF, Neut
- Human Anti-OLR1 Recombinant Antibody (clone CBLFY10) (HPAB-0308-FY)
-
- Derivation: Humanized
- Species Reactivity: Mouse, Chicken
- Type: Humanized IgG
- Application: ELISA
- Chicken Anti-OLR1 Recombinant Antibody (clone HUC52); scFv Fragment (HPAB-0012-CN-S(P))
-
- Derivation: Phage display library
- Species Reactivity: Human, Rabbit, Pig
- Type: Chicken scFv
- Application: WB, ELISA, FC
- Human Anti-OLR1 Recombinant Antibody; Fab Fragment (HPAB-0469-YJ-F(E)) (HPAB-0469-YJ-F(E))
-
- Species Reactivity: Human, Cynomolgus monkey
- Type: Human Fab
- Application: ELISA, FC, Inhib
- Human Anti-OLR1 Recombinant Antibody; Fab Fragment (HPAB-0468-YJ-F(E)) (HPAB-0468-YJ-F(E))
-
- Species Reactivity: Human, Cynomolgus monkey
- Type: Human Fab
- Application: ELISA, FC, Inhib
- Rat Anti-OLR1 Recombinant Antibody (clone 33F1); Fab Fragment (HPAB-1362-FY-S(P))
-
- Species Reactivity: Mouse
- Type: Rat Fab
- Application: ELISA
- Rat Anti-OLR1 Recombinant Antibody (clone 11A2); Fab Fragment (HPAB-1361-FY-S(P))
-
- Species Reactivity: Mouse
- Type: Rat Fab
- Application: ELISA
- Mouse Anti-OLR1 Recombinant Antibody; Fab Fragment (TAB-0687CL-F(E)) (TAB-0687CL-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
- Human Anti-OLR1 Recombinant Antibody; scFv Fragment (HPAB-0468-YJ-S(P)) (HPAB-0468-YJ-S(P))
-
- Species Reactivity: Human, Cynomolgus monkey
- Type: Human scFv
- Application: ELISA, FC, Inhib
- Human Anti-OLR1 Recombinant Antibody (clone CBLFY10); Fab Fragment (HPAB-0308-FY-F(E))
-
- Derivation: Humanized
- Species Reactivity: Mouse, Chicken
- Type: Humanized Fab
- Application: ELISA
- Chicken Anti-OLR1 Recombinant Antibody (clone HUC3-48); Fab Fragment (HPAB-0072-LS-F(E))
-
- Derivation: Chicken
- Species Reactivity: Human, Mouse
- Type: Chicken Fab
- Application: Inhib, ELISA
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