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    OLR1

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    Anti-OLR1 Products

    • Human Anti-OLR1 Antibody, mRNA (TAB-0692CL-mRNA)
      • Species Reactivity: Human, Bovine, Pig and Rabbit (Exhibited various types of cross-reactivity profiles)
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    • Anti-Human OLR1 Recombinant Antibody (TAB-0692CL)
      • Species Reactivity: Bovine, pig, and rabbit (Exhibited various types of cross-reactivity profiles)
      • Type: Human antibody
      • Application: ELISA
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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
    Protein class

    Disease related genes

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Macrophages, Hofbauer cells)

    Immune cell specificity

    Immune cell enhanced (myeloid DC)

    Cell line specificity

    Cell line enhanced (CACO-2, HaCaT, HHSteC, hTCEpi, SiHa, SK-BR-3)

    Interaction

    Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70. (Microbial infection) Binds to the head and beginning of the coiled stalk of N. meningitidis adhesin A (nadA) variant 3; binding can be abrogated by monoclonal antibodies against the specific regions of NadA. Binding occurs in protein microarrays, in solution and when LOX-1 is expressed on the cell surface.

    Molecular function

    Receptor

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