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For Research Use Only. Not For Clinical Use.
Disease related genes
Intracellular, Membrane (different isoforms)
Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Macrophages, Hofbauer cells)
Immune cell enhanced (myeloid DC)
Cell line enhanced (CACO-2, HaCaT, HHSteC, hTCEpi, SiHa, SK-BR-3)
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70. (Microbial infection) Binds to the head and beginning of the coiled stalk of N. meningitidis adhesin A (nadA) variant 3; binding can be abrogated by monoclonal antibodies against the specific regions of NadA. Binding occurs in protein microarrays, in solution and when LOX-1 is expressed on the cell surface.
Receptor