Recombinant Anti-P2RX7 Vesicular Antibody, EV Displayed (VS-0425-YC286)
CAT#: VS-0425-YC286
The Recombinant Anti-P2RX7 Vesicular Antibody, EV Displayed (VS-0425-YC286) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to P2RX7-expressed cells or tissues. The P2RX7 is a purinoceptor that forms ATP-dependent ion channels, influencing immunity and cellular responses.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows moderate positivity in neuropil.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_8_5_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows weak positivity in neuropil.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/42013/103582_B_7_5_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_4_6.jpg
Normal Tissue
Figure 7 Skin
Keratinocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_8_1.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Karpas-707, RPMI-8226, SK-MEL-30, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089041-P2RX7
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- P2RX7
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Purinergic receptor P2X 7
- Biological Process
- Ion transport, Transport
- Molecular Function
- Ion channel, Ligand-gated ion channel, Receptor
- Introduction
- The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
- Alternative Names
- MGC20089, P2X7
- Gene ID
- 5027
- UniProt ID
- Q99572
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Datasheet
MSDS
COA
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See other products for "P2RX7"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2843z | Mouse Anti-P2RX7 Recombinant Antibody (clone 24F9) | WB, ELISA, FC, IHC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0916CL | Human Anti-P2RX7 Recombinant Antibody (TAB-0916CL) | WB, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0916CL-S(P) | Human Anti-P2RX7 Recombinant Antibody; scFv Fragment (TAB-0916CL-S(P)) | WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0916CL-F(E) | Human Anti-P2RX7 Recombinant Antibody; Fab Fragment (TAB-0916CL-F(E)) | WB, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0078CL-VHH | Anti-Human P2RX7 VHH Single Domain Antibody (TAB-0078CL-VHH) | FC | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0079CL-VHH | Llama Anti-P2RX7 Recombinant Antibody (TAB-0079CL-VHH) | FC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2565 | Hi-Affi™ Recombinant Rabbit Anti-P2RX7 Monoclonal Antibody (DS2565AB) | WB, IP, FC, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1590-FY | Mouse Anti-P2RX7 Recombinant Antibody (HPAB-1590-FY) | FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1590-FY-F(E) | Mouse Anti-P2RX7 Recombinant Antibody; Fab Fragment (HPAB-1590-FY-F(E)) | Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1590-FY-S(P) | Mouse Anti-P2RX7 Recombinant Antibody; scFv Fragment (HPAB-1590-FY-S(P)) | Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK121 | Mouse Anti-P2RX7 Recombinant Antibody (clone G1-D6) | WB, ELISA | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS7-0425-WR535 | Mouse Anti-P2RX7 Recombinant Antibody (clone 7G1D6) | WB, IHC, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5129 | Anti-P2RX7 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5130 | Anti-Mouse P2RX7 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1225-YC11 | Rabbit Anti-P2RX7 Polyclonal Antibody (VS-1225-YC11) | WB, IHC, IF, FC, ELISA | Rabbit IgG |
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