Recombinant Anti-P2RX7 Vesicular Antibody, EV Displayed (VS-0425-YC286) (CAT#: VS-0425-YC286)
The Recombinant Anti-P2RX7 Vesicular Antibody, EV Displayed (VS-0425-YC286) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to P2RX7-expressed cells or tissues. The P2RX7 is a purinoceptor that forms ATP-dependent ion channels, influencing immunity and cellular responses.
Specific Inquiry
Normal Tissue
RNA Expression

Figure 1 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows moderate positivity in neuropil.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_8_5_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows moderate positivity in neuropil.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_8_5_selected.jpg

Figure 2 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows weak positivity in neuropil.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42013/103582_B_7_5_selected.jpg
(Immunohistochemical staining of human cerebral cortex shows weak positivity in neuropil.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42013/103582_B_7_5_selected.jpg

Figure 3 Cerebral cortex
(Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_7_5.jpg
(Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_7_5.jpg

Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_9_3.jpg

Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_9_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_9_5.jpg

Figure 6 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_A_4_6.jpg

Figure 7 Skin
(Keratinocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_8_1.jpg
(Keratinocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/34968/68670_B_8_1.jpg

Figure 8 RNA cell line category: Cell line enhanced (Karpas-707, RPMI-8226, SK-MEL-30, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089041-P2RX7
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089041-P2RX7
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- P2RX7
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Purinergic receptor P2X 7
- Biological Process
- Ion transport, Transport
- Molecular Function
- Ion channel, Ligand-gated ion channel, Receptor
- Introduction
- The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
- Alternative Names
- MGC20089, P2X7
- Gene ID
- 5027
- UniProt ID
- Q99572
Downloads
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2843z | Mouse Anti-P2RX7 Recombinant Antibody (clone 24F9) | WB, ELISA, FC, IHC | Mouse IgG2b |
HPAB-1590-FY | Mouse Anti-P2RX7 Recombinant Antibody (HPAB-1590-FY) | FC | Mouse IgG2a |
VS3-WK121 | Mouse Anti-P2RX7 Recombinant Antibody (clone G1-D6) | WB, ELISA | Mouse IgG2b |
VS7-0425-WR535 | Mouse Anti-P2RX7 Recombinant Antibody (clone 7G1D6) | WB, IHC, FC | Mouse IgG2b |
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