P2RX7
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA, FC, IHC
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- Human Anti-P2RX7 Recombinant Antibody (TAB-0916CL) (TAB-0916CL)
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- Species Reactivity: Human
- Type: Human IgG
- Application: WB, FC
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- Human Anti-P2RX7 Recombinant Antibody; Fab Fragment (TAB-0916CL-F(E)) (TAB-0916CL-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: WB, FC
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- Mouse Anti-P2RX7 Recombinant Antibody (HPAB-1590-FY) (HPAB-1590-FY)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC
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- Human Anti-P2RX7 Antibody, mRNA (TAB-701CL-mRNA)
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- Species Reactivity: Human
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- Human Anti-P2RX7 Recombinant Antibody; scFv Fragment (TAB-0916CL-S(P)) (TAB-0916CL-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, FC
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- Mouse Anti-P2RX7 Recombinant Antibody; Fab Fragment (HPAB-1590-FY-F(E)) (HPAB-1590-FY-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: Inhib
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- Mouse Anti-P2RX7 Recombinant Antibody; scFv Fragment (HPAB-1590-FY-S(P)) (HPAB-1590-FY-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: Inhib
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- Anti-Human P2RX7 VHH Single Domain Antibody (TAB-0078CL-VHH) (TAB-0078CL-VHH)
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- Derivation: Phage display library
- Type: Single domain antibody
- Application: FC
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- Llama Anti-P2RX7 Recombinant Antibody (TAB-0079CL-VHH) (TAB-0079CL-VHH)
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- Species Reactivity: Human
- Type: Llama VHH
- Application: FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FC, ICC, IF
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- Mouse Anti-P2RX7 Recombinant Antibody (clone 7G1D6) (VS7-0425-WR535)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC, FC
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- Species Reactivity: Human
- Target: P2RX7
- Host Animal: Human
- Application: ELISA, FC, Cell-uptake
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- Rabbit Anti-P2RX7 Polyclonal Antibody (VS-1225-YC11) (VS-1225-YC11)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IF, FC, ELISA
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- Anti-P2RX7 Immunohistochemistry Kit (VS-0525-XY5129)
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- Species Reactivity: Human
- Target: P2RX7
- Application: IHC
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- Anti-Mouse P2RX7 Immunohistochemistry Kit (VS-0525-XY5130)
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- Species Reactivity: Human, Mouse
- Target: P2RX7
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.
Protein class
Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Excitatory neurons)
Immune cell specificity
Group enriched (intermediate monocyte, non-classical monocyte, classical monocyte, myeloid DC, T-reg, gdT-cell)
Cell line specificity
Cell line enhanced (Karpas-707, RPMI-8226, SK-MEL-30, U-266/70, U-266/84)
Interaction
Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB. Interacts (via C-terminus) with EMP2 (PubMed:12107182).
Molecular function
Ion channel, Ligand-gated ion channel, Receptor
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